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Rational design of enzyme activity and enantioselectivity
The strategy of rational design to engineer enzymes is to predict the potential mutants based
on the understanding of the relationships between protein structure and function, and …
on the understanding of the relationships between protein structure and function, and …
Unlocking the potential of enzyme engineering via rational computational design strategies
Enzymes play a pivotal role in various industries by enabling efficient, eco-friendly, and
sustainable chemical processes. However, the low turnover rates and poor substrate …
sustainable chemical processes. However, the low turnover rates and poor substrate …
Resha** substrate-binding pocket of leucine dehydrogenase for bidirectionally accessing structurally diverse substrates
T Wu, Y Wang, N Zhang, D Yin, Y Xu, Y Nie, X Mu - ACS Catalysis, 2022 - ACS Publications
Steric hindrance modification-based pocket resha** is an effective approach for enzyme–
substrate acceptance evolution. However, previous studies were limited to using the …
substrate acceptance evolution. However, previous studies were limited to using the …
Classification and functional origins of stereocomplementary alcohol dehydrogenases for asymmetric synthesis of chiral secondary alcohols: a review
L Zhang, Z Sun, G Xu, Y Ni - International Journal of Biological …, 2024 - Elsevier
Alcohol dehydrogenases (ADHs) mediated biocatalytic asymmetric reduction of ketones
have been widely applied in the synthesis of optically active secondary alcohols with highly …
have been widely applied in the synthesis of optically active secondary alcohols with highly …
Q Yan, X Zhang, Y Chen, B Guo, P Zhou, B Chen… - ACS …, 2022 - ACS Publications
Glucose dehydrogenase (GDH) generally functions as an expensive cofactor NAD (P) H
regenerator in an enzyme-coupled cofactor regeneration system, as in the production of fine …
regenerator in an enzyme-coupled cofactor regeneration system, as in the production of fine …
Ene-reductase-catalyzed enantioselective desymmetrization of cyclohexadienones: straightforward access to all-carbon quaternary stereocenters
X Wu, L Yang, Z Liu, K Zhang, Z Huang, F Chen - ACS Catalysis, 2024 - ACS Publications
An unprecedented enzyme-catalyzed enantioselective desymmetrization of achiral 2, 5-
cyclohexadienones has been reported. Using ene-reductases as the biocatalysts, a variety …
cyclohexadienones has been reported. Using ene-reductases as the biocatalysts, a variety …
Batch and continuous flow asymmetric synthesis of anabolic-androgenic steroids via a single-cell biocatalytic Δ 1-dehydrogenation and C17β-carbonyl reduction …
Y Zhang, M Liu, Z Yang, J Lin, Z Huang, F Chen - Green Chemistry, 2023 - pubs.rsc.org
Chemoenzymatic asymmetric synthesis of an anabolic-androgenic steroid (+)-boldenone (3)
and its prodrug (+)-boldenone undecylenate (4) was accomplished starting from …
and its prodrug (+)-boldenone undecylenate (4) was accomplished starting from …