Tumours display an astonishing variation in the spatial distribution, composition and
activation state of immune cells, which impacts their progression and response to …

Immune evasion is a hallmark of cancer, enabling tumors to survive contact with the host
immune system and evade the cycle of immune recognition and destruction. Here, we …

Abstract The Natural Killer Group 2D (NKG2D) receptor plays an important role in protecting
the host from infections and cancer. By recognizing ligands induced on infected or tumor …

A small proportion of cancer cells that have stem cell-like properties are known as cancer
stem cells (CSCs). They can be used to identify malignant tumor phenotypes and patients …

Immunocheckpoint inhibitors targeting the programmed cell death-1 (PD-1) and PD-1 ligand
1 (PD-L1) axis have shown promising results in patients with non-small-cell lung cancer …

The activating natural killer group 2 member D (NKG 2 D) receptor is expressed on NK cells,
cytotoxic T cells and additional T cell subsets. Ligands for human NKG 2 D comprise two …

Simple Summary Immune surveillance during periods of cellular stress is necessary to
maintain homeostasis. In distressed cells, the expression of stress (natural killer group 2 …

Metabolic reprogramming and immune evasion are two hallmarks of cancer. Metabolic
reprogramming is exemplified by cancer's propensity to utilize glucose at an exponential …

Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype that lacks
estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 …

The antitumor functions of NK cells are regulated by the integration of positive and negative
signals triggered by numerous membrane receptors present on the NK cells themselves …