Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from
anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag …

Neutrophils are becoming recognized as highly versatile and sophisticated cells that display
de novo synthetic capacity and potentially prolonged lifespan. Emerging concepts such as …

Recent clinical studies indicate a strong link between AKI and progression of CKD. The
increasing prevalence of AKI must compel the nephrology community to consider the long …

Critically ill patients are at highest risk for acute kidney injury (AKI), or abrupt renal
dysfunction. Before 2004, most pediatric AKI literature reported on the technical feasibility …

Critical illness is often complicated by acute kidney injury (AKI). In patients with severe AKI,
renal replacement therapy (RRT) is deployed to address metabolic dysfunction and volume …

OBJECTIVE: To characterize the epidemiology of and identify risk factors for neonatal
cardiac surgery–associated acute kidney injury (CS-AKI) and determine its impact on clinical …

Objective: Fluid overload has been independently associated with increased morbidity and
mortality in pediatric patients with renal failure, acute lung injury, and sepsis. Pediatric …

In the past two decades, a substantial increase in the incidence of acute kidney injury (AKI)
and kidney injury requiring dialysis has occurred in North America. This increase has …

Importance Acute kidney injury (AKI) after pediatric cardiac surgery is associated with high
short-term morbidity and mortality; however, the long-term kidney outcomes are unclear …

BACKGROUND: The RIFLE criteria (risk, injury, failure, loss, and end-stage kidney disease)
have been used to assess acute kidney injury (AKI) in various populations of critically ill …