Oligomers which form during amyloid fibril assembly are considered to be key contributors
towards amyloid disease. However, understanding how such intermediates form, their …

Ion mobility spectrometry is an analytical technique known for more than 100 years, which
entails separating ions in the gas phase based on their size, shape, and charge. While ion …

Objective: This review focuses on the current knowledge on the implication and significance
of beta 2 microglobulin (β2M), a conservative immune molecule in vertebrate. Data Sources …

Protein misfolding and aggregation are known to play a crucial role in a number of important
human diseases (Alzheimer's, Parkinson's, prion, diabetes, cataracts, etc.) as well as in a …

Mass spectrometry (MS) is increasingly being used to probe the structure and dynamics of
proteins and the complexes they form with other macromolecules. There are now several …

Native mass spectrometry is widely used to determine the stoichiometries and binding
constants of noncovalent interactions in solution. One challenge is that multiple analytes in a …

Mutation-derived neoantigens are taking central stage as a determinant in eliciting effective
antitumor immune responses following adoptive T-cell therapies. These mutations are …

Capturing the dynamic interplay between proteins and their myriad interaction partners is
critically important for advancing our understanding of almost every biochemical process …

Abstract Beta 2 microglobulin (Β2M) is expressed in all nucleated cells, it interplays with
mediators to regulate and modulate cellular functions. Its role in aging associated disorders …

The aggregation and deposition of α-synuclein in Lewy bodies is associated with the
progression of Parkinson's disease. Here, Mass Spectrometry (MS) is used in combination …