Introduction Asthma is characterized by enhanced airway contractility and remodeling where
airway smooth muscle (ASM) plays a key role, modulated by inflammation. Understanding …

The diacylglycerol kinase family, which can attenuate diacylglycerol signaling and activate
phosphatidic acid signaling, regulates various signaling transductions in the mammalian …

Epigenetic modifications such as DNA methylation play an essential role in imprinting
specific transcriptional patterns in cells. We performed genome-wide DNA methylation …

Background Sepsis is an abnormal immune response after infection, wherein the lung is the
most susceptible organ to fail, leading to acute lung injury. To overcome the limitations of …

Exaggerated airway smooth muscle (ASM) contraction regulated by the Gq family of G
protein-coupled receptors causes airway hyperresponsiveness in asthma. Activation of Gq …

Background Diacylglycerol kinase (DGK) regulates intracellular signaling and functions by
converting diacylglycerol (DAG) into phosphatidic acid. We previously demonstrated that …

Diacylglycerol kinase (DGK), a lipid kinase, catalyzes the conversion of diacylglycerol (DAG)
to phosphatidic acid, thereby terminating DAG‐mediated signaling by Gq‐coupled receptors …

Airway remodeling in asthma involves the hyperproliferation of airway smooth muscle (ASM)
cells. However, the molecular signals that regulate ASM growth are not completely …

Probiotics should be administered in adequate amounts to confer health benefits. Probiotic
dose–response studies are still missing. Saccharomyces cerevisiae UFMG A-905 prevented …

To contract, to deform, and remodel, the airway smooth muscle (ASM) cell relies on dynamic
changes in the structure of its mechanical force-bearing cytoskeleton. These alternate …