Ten years ago, a consensus report on the optimization of tacrolimus was published in this
journal. In 2017, the Immunosuppressive Drugs Scientific Committee of the International …

Many cancer type-specific anticancer agents have been developed and significant
advances have been made toward precision medicine in cancer treatment. However …

Epilepsy is a common neurological disorder that affects over 70 million people worldwide.
Despite the recent introduction of new antiseizure drugs (ASDs), about one-third of patients …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms. The processes are usually mediated by specific transporters. One of the …

Over the past 15 years, sequencing of the human genome and The Cancer Genome Atlas
(TCGA) project have led to comprehensive lists of single-nucleotide polymorphisms (SNPs) …

The interindividual genetic variations in drug metabolizing enzymes and transporters
influence the efficacy and toxicity of numerous drugs. As a fundamental element in precision …

Novel immune checkpoint blockade with ipilimumab, an antibody blocking the cytotoxic T-
lymphocyte antigen 4 (CTLA4), is revolutionizing cancer therapy. However, ipilimumab …

▪ Abstract The design of cancer chemotherapy has become increasingly sophisticated, yet
there is no cancer treatment that is 100% effective against disseminated cancer. Resistance …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms and a large number of specific transporters have evolved to carry out this …

Synonymous single-nucleotide polymorphisms (SNPs) do not produce altered coding
sequences, and therefore they are not expected to change the function of the protein in …