Cancer immunogenomics is an emerging field that bridges genomics and immunology. The
establishment of large-scale genomic collaborative efforts along with the development of …

The treatment of cancer was revolutionized within the last two decades by utilizing the
mechanism of the immune system against malignant tissue in so-called cancer …

RNA splicing is an essential process that governs many aspects of cellular proliferation,
survival, and differentiation. Considering the importance of RNA splicing in gene regulation …

Background Long-read sequencing of full-length cDNAs enables the detection of structures
of aberrant splicing isoforms in cancer cells. These isoforms are occasionally translated …

The development of cancer vaccines to induce tumor-antigen specific immune responses
was sparked by the identification of antigens specific to or overexpressed in cancer cells …

Neoantigen discovery in pediatric brain tumors is hampered by their low mutational burden
and scant tissue availability. Here we develop a proteogenomic approach combining tumor …

Although immune checkpoint inhibitors have changed the treatment paradigm of a variety of
cancers, including non-small-cell lung cancer, not all patients respond to immunotherapy in …

The genome of cancer cells contains circular extrachromosomal DNA (ecDNA) elements not
found in normal cells. Analysis of clinical samples reveal they are common in most cancers …

Medulloblastoma is an aggressive brain tumor that occurs predominantly in children.
Despite intensive therapy, many patients die of the disease, and novel therapies are …

Background Compared with adult cancers, pediatric cancers are uniquely characterized by
a genomically stable landscape and lower tumor mutational burden. Alternative splicing …