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Clusterin in Alzheimer's disease: mechanisms, genetics, and lessons from other pathologies
Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …
[HTML][HTML] Inflammation, extracellular matrix remodeling, and proteostasis in tumor microenvironment
M Marozzi, A Parnigoni, A Negri, M Viola… - International journal of …, 2021 - mdpi.com
Cancer is a multifaceted and complex pathology characterized by uncontrolled cell
proliferation and decreased apoptosis. Most cancers are recognized by an inflammatory …
proliferation and decreased apoptosis. Most cancers are recognized by an inflammatory …
Single-cell characterization of malignant phenotypes and developmental trajectories of adrenal neuroblastoma
R Dong, R Yang, Y Zhan, HD Lai, CJ Ye, XY Yao… - Cancer Cell, 2020 - cell.com
Neuroblastoma (NB), which is a subtype of neural-crest-derived malignancy, is the most
common extracranial solid tumor occurring in childhood. Despite extensive research, the …
common extracranial solid tumor occurring in childhood. Despite extensive research, the …
Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1
Immunotherapy with anti-GD2 antibodies has advanced the treatment of children with high-
risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms …
risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms …
An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED
W Qi, K Zhao, J Gu, Y Huang, Y Wang, H Zhang… - Nature chemical …, 2017 - nature.com
Abstract Polycomb repressive complex 2 (PRC2) consists of three core subunits, EZH2, EED
and SUZ12, and plays pivotal roles in transcriptional regulation. The catalytic subunit EZH2 …
and SUZ12, and plays pivotal roles in transcriptional regulation. The catalytic subunit EZH2 …
Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma
Amplification of the locus encoding the oncogenic transcription factor MYCN is a defining
feature of high-risk neuroblastoma. Here we present the first dynamic chromatin and …
feature of high-risk neuroblastoma. Here we present the first dynamic chromatin and …
The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation
Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most
common extracranial tumor of childhood. By sequencing transcriptomes of low-and high-risk …
common extracranial tumor of childhood. By sequencing transcriptomes of low-and high-risk …
Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer
W Kim, GH Bird, T Neff, G Guo, MA Kerenyi… - Nature chemical …, 2013 - nature.com
Enhancer of zeste homolog 2 (EZH2) is the histone lysine N-methyltransferase component
of the Polycomb repressive complex 2 (PRC2), which, in conjunction with embryonic …
of the Polycomb repressive complex 2 (PRC2), which, in conjunction with embryonic …
Origin and initiation mechanisms of neuroblastoma
S Tsubota, K Kadomatsu - Cell and tissue research, 2018 - Springer
Neuroblastoma is an embryonal malignancy that affects normal development of the adrenal
medulla and paravertebral sympathetic ganglia in early childhood. Extensive studies have …
medulla and paravertebral sympathetic ganglia in early childhood. Extensive studies have …
[HTML][HTML] Regulation and role of EZH2 in cancer
Abstract Polycomb repressive complex 2 (PRC2) is the epigenetic regulator that induces
histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription …
histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription …