How to measure and evaluate binding affinities
Quantitative measurements of biomolecule associations are central to biological
understanding and are needed to build and test predictive and mechanistic models. Given …
understanding and are needed to build and test predictive and mechanistic models. Given …
A new lens for RNA localization: liquid-liquid phase separation
EM Langdon, AS Gladfelter - Annual Review of Microbiology, 2018 - annualreviews.org
RNA localization mechanisms have been intensively studied and include localized
protection of mRNA from degradation, diffusion-coupled local entrapment of mRNA, and …
protection of mRNA from degradation, diffusion-coupled local entrapment of mRNA, and …
let-7 microRNAs: Their Role in Cerebral and Cardiovascular Diseases, Inflammation, Cancer, and Their Regulation
DL Bernstein, X Jiang, S Rom - Biomedicines, 2021 - mdpi.com
The let-7 family is among the first microRNAs found. Recent investigations have indicated
that it is highly expressed in many systems, including cerebral and cardiovascular systems …
that it is highly expressed in many systems, including cerebral and cardiovascular systems …
hnRNP A1 dysfunction alters RNA splicing and drives neurodegeneration in multiple sclerosis (MS)
Neurodegeneration is the primary driver of disease progression in multiple sclerosis (MS)
resulting in permanent disability, creating an urgent need to discover its underlying …
resulting in permanent disability, creating an urgent need to discover its underlying …
Recognition of the TDP-43 nuclear localization signal by importin α1/β
Cytoplasmic mislocalization of the TAR-DNA binding protein of 43 kDa (TDP-43) leads to
large, insoluble aggregates that are a hallmark of amyotrophic lateral sclerosis and …
large, insoluble aggregates that are a hallmark of amyotrophic lateral sclerosis and …
Phase separation of heterogeneous nuclear ribonucleoprotein A1 upon specific RNA‐binding observed by magnetic resonance
Interaction of heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) with specific single‐
stranded RNA and its relation to liquid‐liquid phase separation (LLPS) were studied in vitro …
stranded RNA and its relation to liquid‐liquid phase separation (LLPS) were studied in vitro …
Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export
Nuclear clearance of the RNA-binding protein TDP-43 is a hallmark of neurodegeneration
and an important therapeutic target. Our current understanding of TDP-43 …
and an important therapeutic target. Our current understanding of TDP-43 …
Tandem hnRNP A1 RNA recognition motifs act in concert to repress the splicing of survival motor neuron exon 7
HnRNP A1 regulates many alternative splicing events by the recognition of splicing silencer
elements. Here, we provide the solution structures of its two RNA recognition motifs (RRMs) …
elements. Here, we provide the solution structures of its two RNA recognition motifs (RRMs) …
A quantitative and predictive model for RNA binding by human Pumilio proteins
High-throughput methodologies have enabled routine generation of RNA target sets and
sequence motifs for RNA-binding proteins (RBPs). Nevertheless, quantitative approaches …
sequence motifs for RNA-binding proteins (RBPs). Nevertheless, quantitative approaches …
HnRNP A1 alters the structure of a conserved enterovirus IRES domain to stimulate viral translation
Enteroviruses use a type I Internal Ribosome Entry Site (IRES) structure to facilitate protein
synthesis and promote genome replication. Type I IRES elements require auxiliary host …
synthesis and promote genome replication. Type I IRES elements require auxiliary host …