The challenge of cartilage integration: understanding a major barrier to chondral repair
A Trengove, C Di Bella, AJ O'Connor - Tissue Engineering Part B …, 2022 - liebertpub.com
Articular cartilage defects caused by injury frequently lead to osteoarthritis, a painful and
costly disease. Despite widely used surgical methods to treat articular cartilage defects and …
costly disease. Despite widely used surgical methods to treat articular cartilage defects and …
Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes
Osteoarthritis is a chronic disease that can be initiated by altered joint loading or injury of the
cartilage. The mechanically sensitive PIEZO ion channels have been shown to transduce …
cartilage. The mechanically sensitive PIEZO ion channels have been shown to transduce …
[HTML][HTML] The intrinsic quality of proteoglycans, but not collagen fibres, degrades in osteoarthritic cartilage
The function of articular cartilage as a load-bearing connective tissue is derived primarily
from a balanced interaction between the swelling proteoglycan (PG) matrix and tension …
from a balanced interaction between the swelling proteoglycan (PG) matrix and tension …
Microscale investigation of the anisotropic swelling of cartilage tissue and cells in response to hypo‐osmotic challenges
Tissue swelling represents an early sign of osteoarthritis, reflecting osmolarity changes from
iso‐to hypo‐osmotic in the diseased joints. Increased tissue hydration may drive cell …
iso‐to hypo‐osmotic in the diseased joints. Increased tissue hydration may drive cell …
[HTML][HTML] Collagen fibres determine the crack morphology in articular cartilage
Cracks in articular cartilage compromise tissue integrity and mechanical properties and lead
to chondral lesions if untreated. An understanding of the mechanics of cracked cartilage may …
to chondral lesions if untreated. An understanding of the mechanics of cracked cartilage may …
[HTML][HTML] Membrane Ruffles: Composition, Function, Formation and Visualization
G Yan, J Zhou, J Yin, D Gao, X Zhong, X Deng… - International Journal of …, 2024 - mdpi.com
Membrane ruffles are cell actin-based membrane protrusions that have distinct structural
characteristics. Linear ruffles with columnar spike-like and veil-like structures assemble at …
characteristics. Linear ruffles with columnar spike-like and veil-like structures assemble at …
The protective function of directed asymmetry in the pericellular matrix envelo** chondrocytes
The specialized pericellular matrix (PCM) surrounding chondrocytes within articular
cartilage is critical to the tissue's health and longevity. Growing evidence suggests that PCM …
cartilage is critical to the tissue's health and longevity. Growing evidence suggests that PCM …
Functional assessment of human articular cartilage using second harmonic generation (SHG) imaging: a feasibility study
Many arthroscopic tools developed for knee joint assessment are contact-based, which is
challenging for in vivo application in narrow joint spaces. Second harmonic generation …
challenging for in vivo application in narrow joint spaces. Second harmonic generation …
Deformation behaviors and mechanical impairments of tissue cracks in immature and mature cartilages
EK Moo, Y Al‐Saffar, T Le, RA Seerattan… - Journal of …, 2022 - Wiley Online Library
Degeneration of articular cartilage is often triggered by a small tissue crack. As cartilage
structure and composition change with age, the mechanics of cracked cartilage may depend …
structure and composition change with age, the mechanics of cracked cartilage may depend …
Superficial zone chondrocytes can get compacted under physiological loading: A multiscale finite element analysis
Recent in vivo and in vitro studies have demonstrated that superficial zone (SZ)
chondrocytes within articular layers of diarthrodial joints die under normal physiologic …
chondrocytes within articular layers of diarthrodial joints die under normal physiologic …