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Characterizing regional drug delivery within the nasal airways
Introduction The nose has been receiving increased attention as a route for drug delivery. As
the site of deposition constitutes the first point of contact of the body with the drug …
the site of deposition constitutes the first point of contact of the body with the drug …
CFD-PK model for nasal suspension sprays: Validation with human adult in vivo data for triamcinolone acetonide
The objectives of this study were to expand and implement a Computational Fluid Dynamics
(CFD)-Dissolution, Absorption and Clearance (DAC)-Pharmacokinetics (PK) multi-physics …
(CFD)-Dissolution, Absorption and Clearance (DAC)-Pharmacokinetics (PK) multi-physics …
Development of a predictive model for pediatric intranasal drug delivery with nasal sprays: Leveraging intersubject variability in anatomical dimensions, administration …
In this study, we examined the correlation between anatomical dimensions, spray
administration parameters, pressure drop across 40 pediatric nasal cavities, and in vitro …
administration parameters, pressure drop across 40 pediatric nasal cavities, and in vitro …
MicroED Structures of Fluticasone Furoate and Fluticasone Propionate Provide New Insights into Their Function
J Lin, J Unge, T Gonen - Crystal Growth & Design, 2024 - ACS Publications
The detailed understanding of the conformational pathway of fluticasone, a widely
prescribed medicine for allergic rhinitis, asthma, and chronic obstructive pulmonary disease …
prescribed medicine for allergic rhinitis, asthma, and chronic obstructive pulmonary disease …
Optimization of formulation and device design for carrier-based nasal powder of influenza vaccine to maximize the delivery capability to the target site in the nasal …
S Mieda, K Inoue, A Ito, S Yada, M Miyajima… - Journal of Drug Delivery …, 2025 - Elsevier
Previously, a nasal powder formulation of the influenza vaccine was proposed to ensure its
stability over fifteen months at room temperature and to have sufficient moisture-resistant …
stability over fifteen months at room temperature and to have sufficient moisture-resistant …
Prediction of Transport and Deposition of Porous Particles in the Respiratory System Using Eulerian–Lagrangian Approach
Deep lung delivery is crucial for respiratory disease treatment. Although nano and
submicron particles exhibited a good deposition efficiency in deep regions of the lung …
submicron particles exhibited a good deposition efficiency in deep regions of the lung …