T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

The intestinal epithelium, which segregates the highly stimulatory lumen from the underlying
tissue, harbors one of the largest lymphocyte populations in the body, intestinal …

T cell receptor (TCR) β-selection (herein referred to as β-selection) is a pivotal checkpoint in
mammalian T cell development when immature CD4–CD8–T-cells (thymocytes) express pre …

Developmental thymic waves of innate-like and adaptive-like γδ T cells have been
described, but the current understanding of γδ T cell development is mainly limited to mouse …

Lymphatic transport of molecules and migration of myeloid cells to lymph nodes (LNs)
continuously inform lymphocytes on changes in drained tissues. Here, using LN …

Circulating immune cell compartments have been extensively studied for decades, but
limited access to peripheral tissue and cell yield have hampered our understanding of tissue …

For the skin immune system, γδ T cells are important components, which help in defensing
against damage and infection of skin. Compared to the conventional αβ T cells, γδ T cells …

Naked mole-rats (NMRs) are best known for their extreme longevity and cancer resistance,
suggesting that their immune system might have evolved to facilitate these phenotypes …

The T cell receptor (TCR) repertoires of γδ T cells are very different to those of αβ T cells.
While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the …