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The interplay between cytokines and the Kynurenine pathway in inflammation and atherosclerosis
R Baumgartner, MJ Forteza, DFJ Ketelhuth - Cytokine, 2019 - Elsevier
The kynurenine pathway (KP) is the major metabolic route of tryptophan (Trp) metabolism.
Indoleamine 2, 3-dioxygenase (IDO1), the enzyme responsible for the first and rate-limiting …
Indoleamine 2, 3-dioxygenase (IDO1), the enzyme responsible for the first and rate-limiting …
The G protein-coupled receptors deorphanization landscape
C Laschet, N Dupuis, J Hanson - Biochemical Pharmacology, 2018 - Elsevier
G protein-coupled receptors (GPCRs) are usually highlighted as being both the largest
family of membrane proteins and the most productive source of drug targets. However, most …
family of membrane proteins and the most productive source of drug targets. However, most …
Discovery of new GPCR ligands to illuminate new biology
Although a plurality of drugs target G-protein-coupled receptors (GPCRs), most have
emerged from classical medicinal chemistry and pharmacology programs and resemble one …
emerged from classical medicinal chemistry and pharmacology programs and resemble one …
[HTML][HTML] Orphan G protein-coupled receptors: The role in CNS disorders
There are various types of receptors in the central nervous system (CNS). G protein-coupled
receptors (GPCRs) have the highest expression with a wide range of physiological …
receptors (GPCRs) have the highest expression with a wide range of physiological …
The dark sides of the GPCR tree‐research progress on understudied GPCRs
A large portion of the human GPCRome is still in the dark and understudied, consisting even
of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion …
of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion …
Discovery of TAK-041: a potent and selective GPR139 agonist explored for the treatment of negative symptoms associated with schizophrenia
HA Reichard, HH Schiffer, H Monenschein… - Journal of medicinal …, 2021 - ACS Publications
The orphan G-protein-coupled receptor GPR139 is highly expressed in the habenula, a
small brain nucleus that has been linked to depression, schizophrenia (SCZ), and substance …
small brain nucleus that has been linked to depression, schizophrenia (SCZ), and substance …
Systemic and intra-habenular activation of the orphan G protein-coupled receptor GPR139 decreases compulsive-like alcohol drinking and hyperalgesia in alcohol …
GPR139 is an orphan G protein-coupled receptor (GPCR) that is expressed mainly in the
brain, with the highest expression in the medial habenula. The modulation of GPR139 …
brain, with the highest expression in the medial habenula. The modulation of GPR139 …
The role of orphan receptor GPR139 in neuropsychiatric behavior
Abstract Orphan G protein Coupled Receptors (GPCRs) present attractive targets both for
understanding neuropsychiatric diseases and for development of novel therapeutics …
understanding neuropsychiatric diseases and for development of novel therapeutics …
[HTML][HTML] The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone …
GPR139 is an orphan G protein-coupled receptor that is expressed primarily in the brain.
Not much is known regarding the function of GPR139. Recently we have shown that …
Not much is known regarding the function of GPR139. Recently we have shown that …
Development of predictive models for identifying potential S100A9 inhibitors based on machine learning methods
S100A9 is a potential therapeutic target for various disease including prostate cancer,
colorectal cancer, and Alzheimer's disease. However, the sparsity of atomic level data, such …
colorectal cancer, and Alzheimer's disease. However, the sparsity of atomic level data, such …