The development of animal models that demonstrate excessive levels of alcohol
consumption has played an important role in advancing our knowledge about …

Excessive use of alcohol promotes the development of alcohol addiction, but the
understanding of how alcohol-induced brain alterations lead to addiction remains limited. To …

Childhood adversity increases vulnerability to alcohol use disorders and preclinical models
are needed to investigate the underlying neurobiological mechanisms. The present study …

Substance use disorders are chronic, relapsing, and harmful conditions characterized by
executive dysfunction. While there are currently no approved pharmacotherapy options for …

Objective Alcohol abuse causes several neurological disorders. Resveratrol is a natural
polyphenol that occurs as a phytoalexin. In different studies, it has been investigated that …

Excessive alcohol use is often associated with accelerated cognitive decline, and extensive
research using animal models of human alcohol consumption has been conducted into …

Research in the field of preclinical alcohol research, but also science in general, has a
problem: Many published scientific results cannot be repeated. As a result, findings from …

The mesolimbic dopamine pathway plays a major role in drug reinforcement and is likely
involved also in the development of drug addiction. Ethanol, like most addictive drugs …

Alcohol misuse accounts for a sizeable proportion of the global burden of disease, and
Campral®(acamprosate; calcium-bis-(N-acetylhomotaurinate)) is widely used as relapse …

Introduction: Preclinical studies have shown that calcium seems to be the active component
of the anti-craving drug acamprosate (Ca 2+ bis-acetyl-homotaurinate). Clinical effects in …