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[HTML][HTML] 14-3-3 binding motif phosphorylation disrupts Hdac4-organized condensates to stimulate cardiac reprogramming
Cell fate conversion is associated with extensive post-translational modifications (PTMs) and
architectural changes of sub-organelles, yet how these events are interconnected remains …
architectural changes of sub-organelles, yet how these events are interconnected remains …
[HTML][HTML] Protocol for in vitro observation of HDAC4 condensation during induced cardiac reprogramming
L Liu, Z Wang - STAR protocols, 2025 - Elsevier
Here, we present a protocol to monitor and stimulate cardiac reprogramming via the
disruption of Hdac4 condensates mediated by PC14-3-3 activation. We describe steps for …
disruption of Hdac4 condensates mediated by PC14-3-3 activation. We describe steps for …
Transient BRD4 degradation improves cardiac reprogramming by inhibiting macrophage/Oncostatin M induced JAK/STAT pathway
Reprogramming fibroblasts into induced cardiomyocytes (iCMs) holds great potential for
cardiac regeneration. However, low conversion rate both in vitro and in vivo remains a …
cardiac regeneration. However, low conversion rate both in vitro and in vivo remains a …
Design and development of small molecule tags and pro-tags for universal CAR T cells in cancer therapy
LK Kok - 2023 - ourarchive.otago.ac.nz
Cancer remains a major health issue in NZ and worldwide. Conventional treatments such as
surgery, radiation and chemotherapy have limited ability to treat cancers and cause …
surgery, radiation and chemotherapy have limited ability to treat cancers and cause …