Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally
occurring peptides that can combat infections through their direct microbicidal properties …

In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

Host defence peptides (HDPs) are short, cationic amphipathic peptides with diverse
sequences that are produced by various cells and tissues in all complex life forms. HDPs …

Polymorphonuclear neutrophils are the first cells recruited to inflammatory sites and form the
earliest line of defense against invading microorganisms. Neutrophil elastase, proteinase 3 …

Recent in vivo studies indicate that mesenchymal stem cells (MSCs) may have beneficial
effects in the treatment of sepsis induced by bacterial infection. Administration of MSCs in …

Antimicrobial peptides (AMPs) which predominantly act via membrane active mechanisms
have emerged as an exciting class of antimicrobial agents with tremendous potential to …

The pulmonary airways are continuously exposed to bacteria. As a first line of defense
against infection, the airway surface liquid (ASL) contains a complex mixture of antimicrobial …

Cystic fibrosis is a genetic disease caused by mutations in the CFTR gene, whereas chronic
obstructive pulmonary disease (COPD) is mainly caused by environmental factors (mostly …

The respiratory mucus, a viscoelastic gel, effectuates a primary line of the airway defense
when operated by the mucociliary clearance. In chronic respiratory diseases (CRDs), such …

The inability of neutrophils to eradicate Pseudomonas aeruginosa within the cystic fibrosis
(CF) airway eventually results in chronic infection by the bacteria in nearly 80 percent of …