Stress/cell death pathways, neuroinflammation, and neuropathic pain

L Li, T Li, X Qu, G Sun, Q Fu, G Han - Immunological reviews, 2024 - Wiley Online Library
Neuropathic pain is a common and debilitating modality of chronic pain induced by a lesion
or disease of the somatosensory nervous system. Albeit the elucidation of numerous …

Immunotherapies in chronic pain through modulation of neuroimmune interactions

J Zhao, Y Huh, A Bortsov, L Diatchenko… - Pharmacology & …, 2023 - Elsevier
It is generally believed that immune activation can elicit pain through production of
inflammatory mediators that can activate nociceptive sensory neurons. Emerging evidence …

PD-L1/PD-1 pathway: a potential neuroimmune target for pain relief

D Deng, T Zhang, L Ma, W Zhao, S Huang, K Wang… - Cell & Bioscience, 2024 - Springer
Pain is a common symptom of many diseases with a high incidence rate. Clinically, drug
treatment, as the main method to relieve pain at present, is often accompanied by different …

From pain to tumor immunity: influence of peripheral sensory neurons in cancer

U Mardelle, N Bretaud, C Daher, V Feuillet - Frontiers in Immunology, 2024 - frontiersin.org
The nervous and immune systems are the primary sensory interfaces of the body, allowing it
to recognize, process, and respond to various stimuli from both the external and internal …

Sex differences in PD‐L1‐induced analgesia in paclitaxel‐induced peripheral neuropathy mice depend on TRPV1‐based inhibition of CGRP

Y Cao, W Jiang, F Yan, Y Pan, L Gei… - CNS Neuroscience …, 2024 - Wiley Online Library
Aims Paclitaxel (PTX) is extensively utilized in the management of diverse solid tumors,
frequently resulting in paclitaxel‐induced peripheral neuropathy (PIPN). The present study …

Exploring shared targets in cancer immunotherapy and cancer-induced bone pain: Insights from preclinical studies

R Zhang, Y Yang, X Li, C Jiao, M Lou, W Mi… - Cancer Letters, 2025 - Elsevier
Cancer casts a profound shadow on global health, with pain emerging as one of the
dominant and severe complications, particularly in advanced stages. The effective …

Cancer Therapy-induced Dermatotoxicity as a Window to Understanding Skin Immunity

Y Jiménez-Andrade, JL Flesher… - Hematology/Oncology …, 2024 - hemonc.theclinics.com
The advent of targeted molecular therapy and immunotherapy in clinical oncology heralded
explosive growth of data from the clinic that would shed new light on basic biology and …

Development of a nomogram for predicting cancer pain in lung cancer patients: An observational study

Y Li, Z Wang, C Gong, Y Zhang, L Fu, B Wu, W Wang… - Medicine, 2024 - journals.lww.com
During the progression of lung cancer, cancer pain is a common complication. Currently,
there are no accurate tools or methods to predict the occurrence of cancer pain in lung …

[HTML][HTML] Toripalimab combined with bevacizumab plus chemotherapy as first-line treatment for refractory recurrent or metastatic cervical cancer: a single-arm, open …

C Li, S Liu, Y He, H Yao, Z Yuan, J Yang, D Cao… - Journal of Gynecologic …, 2024 - ejgo.org
Objective To evaluate the efficacy and safety of adding toripalimab to bevacizumab and
platinum-based chemotherapy as first-line treatment for refractory recurrent or metastatic …

Dissecting the link between PD-1/PD-L1-based immunotherapy and cancer pain: mechanisms, research implications, and artificial intelligence perspectives

M Cascella, B Miranda, C Gagliardi… - Exploration of …, 2024 - explorationpub.com
Cancer-related pain represents one of the most common complaints of cancer patients
especially for those with advanced-stage of disease and/or bone metastases. More effective …