Cell‐inspired all‐aqueous microfluidics: from intracellular liquid–liquid phase separation toward advanced biomaterials
Living cells have evolved over billions of years to develop structural and functional
complexity with numerous intracellular compartments that are formed due to liquid–liquid …
complexity with numerous intracellular compartments that are formed due to liquid–liquid …
Walking to work: roles for class V myosins as cargo transporters
JA Hammer III, JR Sellers - Nature reviews Molecular cell biology, 2012 - nature.com
Cells use molecular motors, such as myosins, to move, position and segregate their
organelles. Class V myosins possess biochemical and structural properties that should …
organelles. Class V myosins possess biochemical and structural properties that should …
[HTML][HTML] Tau promotes neurodegeneration via DRP1 mislocalization in vivo
B DuBoff, J Götz, MB Feany - Neuron, 2012 - cell.com
Mitochondrial abnormalities have been documented in Alzheimer's disease and related
neurodegenerative disorders, but the causal relationship between mitochondrial changes …
neurodegenerative disorders, but the causal relationship between mitochondrial changes …
α-Tubulin tyrosination and CLIP-170 phosphorylation regulate the initiation of dynein-driven transport in neurons
Motor-cargo recruitment to microtubules is often the rate-limiting step of intracellular
transport, and defects in this recruitment can cause neurodegenerative disease. Here, we …
transport, and defects in this recruitment can cause neurodegenerative disease. Here, we …
Positioning and sha** the nucleus represents a mechanical challenge for the migrating
cell because of its large size and resistance to deformation. Cells shape and position the …
cell because of its large size and resistance to deformation. Cells shape and position the …
Linking molecular motors to membrane cargo
A Akhmanova, JA Hammer III - Current opinion in cell biology, 2010 - Elsevier
Three types of motors, myosins, kinesins, and cytoplasmic dynein, cooperate to transport
intracellular membrane organelles. Transport of each cargo is determined by recruitment of …
intracellular membrane organelles. Transport of each cargo is determined by recruitment of …
Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation
A Klip, Y Sun, TT Chiu, KP Foley - American Journal of …, 2014 - journals.physiology.org
Skeletal muscle is the major tissue disposing of dietary glucose, a function regulated by
insulin-elicited signals that impart mobilization of GLUT4 glucose transporters to the plasma …
insulin-elicited signals that impart mobilization of GLUT4 glucose transporters to the plasma …
[HTML][HTML] Local cytoskeletal and organelle interactions impact molecular-motor-driven early endosomal trafficking
Background In the intracellular environment, motor-driven cargo must navigate a dense
cytoskeletal network among abundant organelles. Results We investigated the effects of the …
cytoskeletal network among abundant organelles. Results We investigated the effects of the …
Reaction‐diffusion systems in intracellular molecular transport and control
Chemical reactions make cells work only if the participating chemicals are delivered to
desired locations in a timely and precise fashion. Most research to date has focused on …
desired locations in a timely and precise fashion. Most research to date has focused on …