Adenomatous polyposis coli (APC) is widely accepted as a tumor suppressor gene highly
mutated in colorectal cancers (CRC). Mutation and inactivation of this gene is a key and …

Dividing cells that experience chromosome mis-segregation generate aneuploid daughter
cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes …

Most solid tumors are aneuploid, having a chromosome number that is not a multiple of the
haploid number, and many frequently mis-segregate whole chromosomes in a phenomenon …

Drugs targeting the mitotic spindle are used extensively during chemotherapy, but
surprisingly, little is known about how they kill tumor cells. This is largely because many of …

Inducible degradation is a powerful approach for identifying the function of a specific protein
or protein complex. Recently, a plant auxin-inducible degron (AID) system has been shown …

Aneuploidy has been recognized as a common characteristic of cancer cells for> 100 years.
Aneuploidy frequently results from errors of the mitotic checkpoint, the major cell cycle …

The adenomatous polyposis coli (APC) gene is a key tumor suppressor gene. Mutations in
the gene have been found not only in most colon cancers but also in some other cancers …

Most solid human tumours are aneuploid, that is, they contain an abnormal number of
chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress …

The aim of this study was to compare BRAF and KRAS, CpG island methylator phenotype
(CIMP), and microsatellite instability (MSI) status in each of the histologic categories …

Kinetochores, multisubunit protein assemblies, connect chromosomes to spindle
microtubules to promote chromosome segregation. The 10-subunit KMN assembly …