Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

A 'principles and practice'tutorial-style review of the application of solution-phase NMR in the
analysis of the mechanisms of homogeneous organic and organometallic reactions and …

Biomolecules are in constant motion. To understand how they function, and why
malfunctions can cause disease, it is necessary to describe their three-dimensional …

NMR spectroscopy is the only method to access the structural dynamics of biomolecules at
high (atomistic) resolution in their native solution state. However, this method's low …

Proteins have dynamic structures that undergo chain motions on time scales spanning from
picoseconds to seconds. Resolving the resultant conformational heterogeneity is essential …

Sampling and genomic efforts over the past decade have revealed an enormous quantity
and diversity of life in Earth's extreme environments. This new knowledge of life on Earth …

Highlights•Sparsely populated protein states can play significant biological roles.•NMR
spectroscopy can structurally and dynamically characterize 'invisible'protein states.•We …

Naturally occurring metamorphic proteins have the ability to interconvert from one folded
state to another through either a limited set of mutations or by way of a change in the local …

Pressure is a key variable in the phase behavior of responsive polymers, both for
applications and from a fundamental point of view. In this feature article, we review recent …

Solvent paramagnetic relaxation enhancement (sPRE) is a versatile nuclear magnetic
resonance (NMR)-based method that allows characterization of the structure and dynamics …