Turnitin
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An updated evolutionary classification of CRISPR–Cas systems
The evolution of CRISPR–cas loci, which encode adaptive immune systems in archaea and
bacteria, involves rapid changes, in particular numerous rearrangements of the locus …
bacteria, involves rapid changes, in particular numerous rearrangements of the locus …
CRISPR-Cas: adapting to change
BACKGROUND The arms race between prokaryotes and their perpetually evolving
predators has fueled the evolution of a defense arsenal. The so-called CRISPR-Cas …
predators has fueled the evolution of a defense arsenal. The so-called CRISPR-Cas …
Annotation and classification of CRISPR-Cas systems
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas (CRISPR-
associated proteins) is a prokaryotic adaptive immune system that is represented in most …
associated proteins) is a prokaryotic adaptive immune system that is represented in most …
Unravelling the structural and mechanistic basis of CRISPR–Cas systems
Bacteria and archaea have evolved sophisticated adaptive immune systems, known as
CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR …
CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR …
CRISPR-mediated adaptive immune systems in bacteria and archaea
Effective clearance of an infection requires that the immune system rapidly detects and
neutralizes invading parasites while strictly avoiding self-antigens that would result in …
neutralizes invading parasites while strictly avoiding self-antigens that would result in …
The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems
CRISPR-Cas is a rapidly evolving RNA-mediated adaptive immune system that protects
bacteria and archaea against mobile genetic elements. The system relies on the activity of …
bacteria and archaea against mobile genetic elements. The system relies on the activity of …
Classification and evolution of type II CRISPR-Cas systems
The CRISPR-Cas systems of archaeal and bacterial adaptive immunity are classified into
three types that differ by the repertoires of CRISPR-associated (cas) genes, the organization …
three types that differ by the repertoires of CRISPR-associated (cas) genes, the organization …
crRNA and tracrRNA guide Cas9-mediated DNA interference in Streptococcus thermophilus
The Cas9-crRNA complex of the Streptococcus thermophilus DGCC7710 CRISPR3-Cas
system functions as an RNA-guided endonuclease with crRNA-directed target sequence …
system functions as an RNA-guided endonuclease with crRNA-directed target sequence …
CRISPR interference directs strand specific spacer acquisition
Background CRISPR/Cas is a widespread adaptive immune system in prokaryotes. This
system integrates short stretches of DNA derived from invading nucleic acids into genomic …
system integrates short stretches of DNA derived from invading nucleic acids into genomic …
Cas9 function and host genome sampling in Type II-A CRISPR–Cas adaptation
To acquire the ability to recognize and destroy virus and plasmid invaders, prokaryotic
CRISPR–Cas systems capture fragments of DNA within the host CRISPR locus. Our results …
CRISPR–Cas systems capture fragments of DNA within the host CRISPR locus. Our results …