Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

Malaria is a major cause of disease and death in tropical countries. A safe and effective
vaccine is essential to achieve significant and sustained reductions in malaria-related …

Background An effective prophylactic vaccine would help control the spread of genital
herpes. Methods We conducted two double-blind, randomized trials of a herpes simplex …

The glycosylphosphatidylinositol (GPI) anchors of Plasmodium falciparum have been
proposed to be the major factors that contribute to malaria pathogenesis through their ability …

Plasmodium parasite–specific antibodies are critical for protection against malaria, yet the
development of long-lived and effective humoral immunity against Plasmodium takes many …

Throughout history malaria has proved to be a significant threat to human health. Between
300 and 500 million clinical cases occur each year worldwide, approximately 2 million of …

CD4+ T-cells have been shown to play a central role in immune control of infection with
Plasmodium parasites. At the erythrocytic stage of infection, IFN-γ production by CD4+ T …

Interferon gamma (IFN-γ) is a key mediator of inflammatory immune responses induced
primarily by interleukin-12 (IL-12). IFN-γ secretion by both innate and adaptive immune cells …

Malaria is caused by the protozoan Plasmodium, transmitted to humans by Anopheles
mosquitoes. The most dangerous of the plasmodia infecting humans is Plasmodium …

Review underscores the ubiquitous contribution of IFN-δ to immune responses against
malaria, evidence for its protective role and critical issues relating to its induction. Immune …