Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed
from a research tool to a clinical application for the diagnosis and management of …

Metagenomic sequencing is a powerful tool for examining the diversity and complexity of
microbial communities. Most widely used tools for taxonomic profiling of metagenomic …

The widespread use of antibiotics has placed bacterial pathogens under intense pressure to
evolve new survival mechanisms. Genomic analysis of 51,229 Mycobacterium tuberculosis …

A small number of high-burden countries account for the majority of tuberculosis cases
worldwide. Detailed data are lacking from these regions. To explore the evolutionary history …

Archaeological dental calculus, or mineralized plaque, is a key tool to track the evolution of
oral microbiota across time in response to processes that impacted our culture and biology …

Tuberculosis (TB) disease can be characterized by genotypic and phenotypic complexity in
Mycobacterium tuberculosis bacilli within a single patient. This microbiological …

Abstract Background Mixed, polyclonal Mycobacterium tuberculosis infection occurs in
natural populations. Develo** an effective method for detecting such cases is important in …

Background Mixed infection with multiple strains of the same pathogen in a single host can
present clinical and analytical challenges. Whole genome sequence (WGS) data can …

Tuberculosis (TB) disease can be characterized by genotypic and phenotypic complexity in
Mycobacterium tuberculosis bacilli within a single patient. This microbiological …

Mycobacterium tuberculosis (Mtb) infection results in a spectrum of clinical and
histopathologic manifestations. It has been proposed that the environmental and immune …