Traditional cancer therapy methods, especially those directed against specific intracellular
targets or signaling pathways, are not powerful enough to overcome tumor heterogeneity …

Introduction The blood–brain barrier (BBB) restricts brain access of virtually all
macromolecules. Receptor-mediated transcytosis (RMT) is one strategy toward their brain …

Because of the blood–brain barrier, only a limited fraction of drugs can penetrate the brain.
As a result, there is a need to take larger doses of the drug, which may result in numerous …

The FDA has predicted that at least 10-20 gene therapy products will be approved by 2025.
The surge in the development of such therapies can be attributed to the advent of safe and …

This study aims to investigate the molecular mechanisms and the neuroprotective effect of
hyaluronic acid modified verapamil-loaded carbon quantum dots (VRH-loaded HA-CQDs) …

Nanoparticles (NPs) are the focus of research efforts that aim to develop successful drug
delivery systems for the brain. Polypeptide nanocarriers are versatile platforms and combine …

Nanomedicine, an area which uses nanomaterials for theragnostic purposes, is advancing
rapidly, particularly in the detection and treatment of neurodegenerative diseases. The …

Finding curable therapies for neurodegenerative disease (ND) is still a worldwide medical
and clinical challenge. Recently, investigations have been made into the development of …

Background Targeting the blood–brain barrier (BBB) is a key step for effective brain delivery
of nanocarriers. We have previously discovered that combinations of BBB nutrient …

The modulation of delivery systems using subarachnoid space is considered a breakthrough
for direct administration of active to the targeted receptor for treating central nervous system …