3D cell culture models as recapitulators of the tumor microenvironment for the screening of anti-cancer drugs
Simple Summary Three-dimensional (3D) cell culture models have been proposed as
alternatives for initial drug screening to increase drug development efficiency. In addition to …
alternatives for initial drug screening to increase drug development efficiency. In addition to …
Replacement, reduction, and refinement of animal experiments in anticancer drug development: the contribution of 3D in vitro cancer models in the drug efficacy …
In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a
bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold …
bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold …
Three‐dimensional culture models to study drug resistance in breast cancer
MF Fisher, SS Rao - Biotechnology and bioengineering, 2020 - Wiley Online Library
Despite recent advances in breast cancer treatment, drug resistance frequently presents as
a challenge, contributing to a higher risk of relapse and decreased overall survival rate. It is …
a challenge, contributing to a higher risk of relapse and decreased overall survival rate. It is …
Applicability of drug response metrics for cancer studies using biomaterials
Bioengineers have built models of the tumour microenvironment (TME) in which to study cell–
cell interactions, mechanisms of cancer growth and metastasis, and to test new therapies …
cell interactions, mechanisms of cancer growth and metastasis, and to test new therapies …
MRI analysis to map interstitial flow in the brain tumor microenvironment
Glioblastoma (GBM), a highly aggressive form of brain tumor, is a disease marked by
extensive invasion into the surrounding brain. Interstitial fluid flow (IFF), or the movement of …
extensive invasion into the surrounding brain. Interstitial fluid flow (IFF), or the movement of …
Co-administration of H-ferritin-doxorubicin and Trastuzumab in neoadjuvant setting improves efficacy and prevents cardiotoxicity in HER2+ murine breast cancer …
F Andreata, A Bonizzi, M Sevieri, M Truffi, M Monieri… - Scientific Reports, 2020 - nature.com
Neoadjuvant chemotherapy has been established as the standard of care for HER2-positive
breast cancer since it allows cancer down-staging, up to pathological complete response …
breast cancer since it allows cancer down-staging, up to pathological complete response …
A patient-designed tissue-engineered model of the infiltrative glioblastoma microenvironment
Glioblastoma is an aggressive brain cancer characterized by diffuse infiltration. Infiltrated
glioma cells persist in the brain post-resection where they interact with glial cells and …
glioma cells persist in the brain post-resection where they interact with glial cells and …
A spheroid whole mount drug testing pipeline with machine-learning based image analysis identifies cell-type specific differences in drug efficacy on a single-cell level
M Vitacolonna, R Bruch, R Schneider, J Jabs, M Hafner… - BMC cancer, 2024 - Springer
Background The growth and drug response of tumors are influenced by their stromal
composition, both in vivo and 3D-cell culture models. Cell-type inherent features as well as …
composition, both in vivo and 3D-cell culture models. Cell-type inherent features as well as …
Assessing drug response in engineered brain microenvironments
Tissue engineered systems are important models for the testing and discovery of
therapeutics against a number of diseases. The use of these models in vitro can expand …
therapeutics against a number of diseases. The use of these models in vitro can expand …
OrgDyn: feature-and model-based characterization of spatial and temporal organoid dynamics
Organoid model systems recapitulate key features of mammalian tissues and enable high
throughput experiments. However, the impact of these experiments may be limited by …
throughput experiments. However, the impact of these experiments may be limited by …