Mounting evidence suggests that the gut microbiome impacts brain development and
function. Gut–brain connections may be mediated by an assortment of microbial molecules …

Polyamines are low molecular weight, aliphatic polycations found in the cells of all living
organisms. Due to their positive charges, polyamines bind to macromolecules such as DNA …

Polyamines are ubiquitous, amine-rich molecules with diverse processes in biology. Recent
work has highlighted that polyamines exert profound roles on the mammalian immune …

Biogenic amines (BAs) represent a considerable toxicological risk in some food products.
Putrescine is one of the most common BAs in food. Its increased occurrence in food may …

Historically, drug research targeted to pain treatment has focused on trying to prevent the
propagation of action potentials in the periphery from reaching the brain rather than …

Background Sodium-glucose cotransporter 2 (SGLT2) and SGLT1 inhibitors may have
additional beneficial metabolic effects on circulating metabolites beyond glucose regulation …

Carbonic anhydrases (CAs, EC 4.2. 1.1) are inhibited by sulfonamides, phenols, and
coumarins. Polyamines such as spermine, spermidine, and many synthetic congeners are …

Infection and injury are two seemingly unrelated processes that often converge on common
innate inflammatory responses mediated by pathogen-or damage-associated molecular …

Polyamines (PAs) have been considered as important molecules for survival. However,
evidence reinforces that PAs are also implicated, directly or indirectly, in pathways …

Ischemic brain injury is a major problem associated with stroke. It has been increasingly
recognized that acid-sensing ion channels (ASICs) contribute significantly to ischemic …