Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias
Various biomarkers are available to support the diagnosis of neurodegenerative diseases in
clinical and research settings. Among the molecular imaging biomarkers, amyloid-PET …
clinical and research settings. Among the molecular imaging biomarkers, amyloid-PET …
Microglia in neurodegeneration
The neuroimmune system is involved in development, normal functioning, aging, and injury
of the central nervous system. Microglia, first described a century ago, are the main …
of the central nervous system. Microglia, first described a century ago, are the main …
Mitochondria and mitochondrial cascades in Alzheimer's disease
RH Swerdlow - Journal of Alzheimer's Disease, 2018 - content.iospress.com
Decades of research indicate mitochondria from Alzheimer's disease (AD) patients differ
from those of non-AD individuals. Initial studies revealed structural differences, and …
from those of non-AD individuals. Initial studies revealed structural differences, and …
Imaging techniques in Alzheimer's disease: a review of applications in early diagnosis and longitudinal monitoring
WM van Oostveen, ECM de Lange - International journal of molecular …, 2021 - mdpi.com
Background. Alzheimer's disease (AD) is a progressive neurodegenerative disorder
affecting many individuals worldwide with no effective treatment to date. AD is characterized …
affecting many individuals worldwide with no effective treatment to date. AD is characterized …
Protein misfolding in neurodegenerative diseases: implications and strategies
P Sweeney, H Park, M Baumann, J Dunlop… - Translational …, 2017 - Springer
A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein
aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse …
aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse …
The impact of amyloid‐beta and tau on prospective cognitive decline in older individuals
Objectives Amyloid‐beta (Aβ) and tau pathologies are commonly observed among clinically
normal older individuals at postmortem and can now be detected with in vivo neuroimaging …
normal older individuals at postmortem and can now be detected with in vivo neuroimaging …
Alzheimer's disease
CA Lane, J Hardy, JM Schott - European journal of neurology, 2018 - Wiley Online Library
Alzheimer's disease, the commonest cause of dementia, is a growing global health concern
with huge implications for individuals and society. In this review, current understanding of …
with huge implications for individuals and society. In this review, current understanding of …
A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer's disease dementia
The advent of tau-targeted PET tracers such as flortaucipir (18F)(flortaucipir, also known as
18F-AV-1451 or 18F-T807) have made it possible to investigate the sequence of …
18F-AV-1451 or 18F-T807) have made it possible to investigate the sequence of …
Resveratrol-selenium nanoparticles alleviate neuroinflammation and neurotoxicity in a rat model of Alzheimer's disease by regulating Sirt1/miRNA-134/GSK3β …
OAR Abozaid, MW Sallam, S El-Sonbaty… - … Trace Element Research, 2022 - Springer
Alzheimer's disease (AD) is a brain disorder associated with a gradual weakening in
neurocognitive functions, neuroinflammation, and impaired signaling pathways. Resveratrol …
neurocognitive functions, neuroinflammation, and impaired signaling pathways. Resveratrol …
In vivo characterization and quantification of neurofibrillary tau PET radioligand 18F-MK-6240 in humans from Alzheimer disease dementia to young controls
Tau PET imaging has potential for elucidating changes in the deposition of
neuropathological tau aggregates that are occurring during the progression of Alzheimer …
neuropathological tau aggregates that are occurring during the progression of Alzheimer …