Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …
public health burden worldwide. The most common form of NCD is metabolic diseases …
Prediction of bio-sequence modifications and the associations with diseases
C Ao, L Yu, Q Zou - Briefings in Functional Genomics, 2021 - academic.oup.com
Modifications of protein, RNA and DNA play an important role in many biological processes
and are related to some diseases. Therefore, accurate identification and comprehensive …
and are related to some diseases. Therefore, accurate identification and comprehensive …
Single-molecule sequencing and optical map** yields an improved genome of woodland strawberry (Fragaria vesca) with chromosome-scale contiguity
Background Although draft genomes are available for most agronomically important plant
species, the majority are incomplete, highly fragmented, and often riddled with assembly …
species, the majority are incomplete, highly fragmented, and often riddled with assembly …
pSuc-Lys: predict lysine succinylation sites in proteins with PseAAC and ensemble random forest approach
Being one type of post-translational modifications (PTMs), protein lysine succinylation is
important in regulating varieties of biological processes. It is also involved with some …
important in regulating varieties of biological processes. It is also involved with some …
iSuc-PseOpt: identifying lysine succinylation sites in proteins by incorporating sequence-coupling effects into pseudo components and optimizing imbalanced training …
Succinylation is a posttranslational modification (PTM) where a succinyl group is added to a
Lys (K) residue of a protein molecule. Lysine succinylation plays an important role in …
Lys (K) residue of a protein molecule. Lysine succinylation plays an important role in …
Improving protein succinylation sites prediction using embeddings from protein language model
Protein succinylation is an important post-translational modification (PTM) responsible for
many vital metabolic activities in cells, including cellular respiration, regulation, and repair …
many vital metabolic activities in cells, including cellular respiration, regulation, and repair …
Large-scale comparative assessment of computational predictors for lysine post-translational modification sites
Lysine post-translational modifications (PTMs) play a crucial role in regulating diverse
functions and biological processes of proteins. However, because of the large volumes of …
functions and biological processes of proteins. However, because of the large volumes of …
Psychosocial stress and cortisol stress reactivity predict breast milk composition
We studied a sample of 146 Polish, exclusively breastfeeding mothers and their healthy
born on time infants to explore the effect of perinatal psychosocial stress on breast milk …
born on time infants to explore the effect of perinatal psychosocial stress on breast milk …
LMPhosSite: a deep learning-based approach for general protein phosphorylation site prediction using embeddings from the local window sequence and pretrained …
Phosphorylation is one of the most important post-translational modifications and plays a
pivotal role in various cellular processes. Although there exist several computational tools to …
pivotal role in various cellular processes. Although there exist several computational tools to …
[HTML][HTML] Prediction of lysine formylation sites using the composition of k-spaced amino acid pairs via Chou's 5-steps rule and general pseudo components
Z Ju, SY Wang - Genomics, 2020 - Elsevier
Lysine formylation is a newly discovered post-translational modification in histones, which
plays a crucial role in epigenetics of chromatin function and DNA binding. In this study, a …
plays a crucial role in epigenetics of chromatin function and DNA binding. In this study, a …