[HTML][HTML] Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents
For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
[HTML][HTML] The biological activities of butyrylcholinesterase inhibitors
S Zhou, G Huang - Biomedicine & pharmacotherapy, 2022 - Elsevier
Acetylcholinesterase (AChE) inhibitor is the first choice for the treatment of Alzheimer's
disease (AD), but it has some defects, such as dose limitation and unsatisfactory long-term …
disease (AD), but it has some defects, such as dose limitation and unsatisfactory long-term …
Synthesis, DFT studies, molecular docking and biological activity evaluation of thiazole-sulfonamide derivatives as potent Alzheimer's inhibitors
Alzheimer's disease is a major public brain condition that has resulted in many deaths, as
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
Synthesis, in vitro bio-evaluation, and molecular docking study of thiosemicarbazone-based isatin/bis-Schiff base hybrid analogues as effective cholinesterase …
Analogues of isatin/bis-Schiff bases based on thiocarbohydrazone (1–16) were synthesized,
characterised using various methods like NMR and HR-ESI-MS, and then tested against the …
characterised using various methods like NMR and HR-ESI-MS, and then tested against the …
New biologically potent benzimidazole‐based‐triazole derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors along with molecular docking study
A series of fifteen hybrid analogs (1–15) based on benzimidazole bearing triazole skeleton
were synthesized and were evaluated for in vitro AChE and BuChE inhibition profile. All the …
were synthesized and were evaluated for in vitro AChE and BuChE inhibition profile. All the …
Synthesis, in vitro α-amylase, α-glucosidase activities and molecular docking study of new benzimidazole bearing thiazolidinone derivatives
We have synthesized a series of benzimidazole bearing thiazolidinone derivatives (1-20),
characterized through NMR and HREI-MS and screened against α-glucosidase and α …
characterized through NMR and HREI-MS and screened against α-glucosidase and α …
Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds
New hybrid thiazolyl–pyrazoline derivatives (4a–k) were obtained through a facile and
versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase …
versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase …
New thiazole-based thiazolidinone derivatives: synthesis, in vitro α-amylase, α-glucosidase activities and silico molecular docking study
A series of thiazole-based thiazolidinone derivatives (1-20) have been synthesized and
evaluated against α-glucosidase and α-amylase enzymes. All derivatives showed good α …
evaluated against α-glucosidase and α-amylase enzymes. All derivatives showed good α …
[HTML][HTML] Imidazopyridine-based thiazole derivatives as potential antidiabetic agents: synthesis, in vitro bioactivity, and in silico molecular modeling approach
A new series of thiazole derivatives (4a-p) incorporating imidazopyridine moiety was
synthesized and assessed for their in vitro potential α-glucosidase potency using acarbose …
synthesized and assessed for their in vitro potential α-glucosidase potency using acarbose …
In vitro α-glucosidase and α-amylase inhibitory potential and molecular docking studies of benzohydrazide based imines and thiazolidine-4-one derivatives
Benzohydrazide based imine derivatives (1c-16c) and thiazolidine-4-one derivatives (1d-
16d) were synthesized and characterized with different spectroscopic techniques ie HREI …
16d) were synthesized and characterized with different spectroscopic techniques ie HREI …