[HTML][HTML] Recent updates on source, biosynthesis, and therapeutic potential of natural flavonoid luteolin: a review

N Muruganathan, AR Dhanapal, V Baskar… - Metabolites, 2022 - mdpi.com
Nature gives immense resources that are beneficial to humankind. The natural compounds
present in plants provide primary nutritional values to our diet. Apart from food, plants also …

The most potent natural pharmaceuticals, cosmetics, and food ingredients isolated from plants with deep eutectic solvents

A Wawoczny, D Gillner - Journal of Agricultural and Food …, 2023 - ACS Publications
There is growing interest in reducing the number of synthetic products or additives and
replacing them with natural ones. The pharmaceutical, cosmetic, and food industries are …

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

TP Lam, NVN Tran, LHD Pham, NVT Lai… - Natural Products and …, 2024 - Springer
Diabetes mellitus remains a major global health issue, and great attention is directed at
natural therapeutics. This systematic review aimed to assess the potential of flavonoids as …

Evaluation of novel 2-(quinoline-2-ylthio) acetamide derivatives linked to diphenyl-imidazole as α-glucosidase inhibitors: Insights from in silico, in vitro, and in vivo …

MK Ghomi, M Noori, M Mirahmad, A Iraji… - European Journal of …, 2024 - Elsevier
The inhibition of the α-glucosidase enzyme is crucial for targeting type 2 diabetes mellitus
(DM). This study introduces a series of synthetic analogs based on thiomethylacetamide …

Luteolin and Vernodalol as Bioactive Compounds of Leaf and Root Vernonia amygdalina Extracts: Effects on α-Glucosidase, Glycation, ROS, Cell Viability, and In …

FM Djeujo, V Stablum, E Pangrazzi, E Ragazzi… - Pharmaceutics, 2023 - mdpi.com
The aqueous decoctions of Vernonia amygdalina (VA) leaves and roots are widely used in
traditional African medicine as an antidiabetic remedy. The amount of luteolin and …

Discovery of a novel chemo-type for TAAR1 agonism via molecular modeling

G Grossi, N Scarano, F Musumeci, M Tonelli, E Kanov… - Molecules, 2024 - mdpi.com
The search for novel effective TAAR1 ligands continues to draw great attention due to the
wide range of pharmacological applications related to TAAR1 targeting. Herein, molecular …

Advances in the natural α‐glucosidase inhibitors

D Şöhretoğlu, G Renda, R Arroo, J **ao, S Sari - Efood, 2023 - Wiley Online Library
Abstract α‐Glucosidase (AG) inhibitors, one of the classes of oral antidiabetics used to treat
type 2 diabetes mellitus, delay digestion and absorption of glucose, which in turn, has a …

[HTML][HTML] Biological activities of seven medicinal plants used in Chiapas, Mexico

L De La Cruz-Jiménez, MA Hernández-Torres… - Plants, 2022 - mdpi.com
Seven medicinal plants from Chiapas, Mexico, used by Native Americans were analyzed,
aiming to improve the understanding of their medicinal properties through the evaluation of …

[HTML][HTML] Synthesis of obovatol and related neolignan analogues as α-glucosidase and α-amylase inhibitors

C Sciacca, N Cardullo, L Pulvirenti, G Travagliante… - Bioorganic …, 2024 - Elsevier
Diabetes mellitus is a metabolic disease characterized by hyperglycemia, which can be
counteracted by the inhibition of α-glucosidase (α-Glu) and α-amylase (α-Amy), enzymes …

[HTML][HTML] Evaluation of honokiol, magnolol and of a library of new nitrogenated neolignans as pancreatic lipase inhibitors

C Sciacca, N Cardullo, L Pulvirenti, A Di Francesco… - Bioorganic …, 2023 - Elsevier
Obesity is a complex disease defined as an excessive amount of body fat. It is considered a
risk factor for several pathologies; therefore, there is an increasing interest in its treatment …