Modelling autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) using mice and zebrafish
Autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) are two
debilitating neurodevelopmental disorders. The former is associated with social impairments …
debilitating neurodevelopmental disorders. The former is associated with social impairments …
The ras superfamily of small gtpases in non-neoplastic cerebral diseases
L Qu, C Pan, SM He, B Lang, GD Gao… - Frontiers in molecular …, 2019 - frontiersin.org
The small GTPases from the Ras superfamily play crucial roles in basic cellular processes
during practically the entire process of neurodevelopment, including neurogenesis …
during practically the entire process of neurodevelopment, including neurogenesis …
[HTML][HTML] RIT2 regulates autophagy lysosomal pathway induction and protects against α-synuclein pathology in a cellular model of Parkinson's disease
Substantial work has been devoted to better understand the contribution of the myriad of
genes that may underly the development of Parkinson's disease (PD) and their role in …
genes that may underly the development of Parkinson's disease (PD) and their role in …
Linking autism spectrum disorders and parkinsonism: clinical and genetic association
AS Mai, CE Yau, FS Tseng, QXJ Foo… - Annals of Clinical …, 2023 - Wiley Online Library
Background Autism spectrum disorders (ASD) comprise many complex and clinically distinct
neurodevelopmental conditions, with increasing evidence linking them to parkinsonism …
neurodevelopmental conditions, with increasing evidence linking them to parkinsonism …
Genomic markers for essential tremor
FJ Jiménez-Jiménez, H Alonso-Navarro… - Pharmaceuticals, 2021 - mdpi.com
There are many reports suggesting an important role of genetic factors in the
etiopathogenesis of essential tremor (ET), encouraging continuing the research for possible …
etiopathogenesis of essential tremor (ET), encouraging continuing the research for possible …
[HTML][HTML] Genetic risk factors for essential tremor: a review
Background: Essential tremor (ET) is a common movement disorder, which is mainly
characterized by bilateral tremor (postural and/or kinetic) in the upper limbs, with other parts …
characterized by bilateral tremor (postural and/or kinetic) in the upper limbs, with other parts …
Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function
Dopamine (DA) signaling is critical for movement, motivation, and addictive behavior. The
neuronal GTPase, Rit2, is enriched in DA neurons (DANs), binds directly to the DA …
neuronal GTPase, Rit2, is enriched in DA neurons (DANs), binds directly to the DA …
Natural selection at the NHLH2 core promoter exceptionally long CA-repeat in human and disease-only genotypes in late-onset neurocognitive disorder
Background: Approximately 2% of the human core promoter short tandem repeats (STRs)
reach lengths of≥ 6 repeats, which may in part be a result of adaptive evolutionary …
reach lengths of≥ 6 repeats, which may in part be a result of adaptive evolutionary …
Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact
Following its evoked release, dopamine (DA) signaling is rapidly terminated by presynaptic
reuptake, mediated by the cocaine-sensitive DA transporter (DAT). DAT surface availability …
reuptake, mediated by the cocaine-sensitive DA transporter (DAT). DAT surface availability …
Silencing Parkinson's risk allele Rit2 sex-specifically compromises motor function and dopamine neuron viability
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease and
arises from dopamine (DA) neuron death selectively in the substantia nigra pars compacta …
arises from dopamine (DA) neuron death selectively in the substantia nigra pars compacta …