Randomized phase II trial of chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: CAO …
E Fokas, M Allgäuer, B Polat, G Klautke… - Journal of Clinical …, 2019 - ascopubs.org
PURPOSE Total neoadjuvant therapy is a new paradigm for rectal cancer treatment. Optimal
scheduling of preoperative chemoradiotherapy (CRT) and chemotherapy remains to be …
scheduling of preoperative chemoradiotherapy (CRT) and chemotherapy remains to be …
Total neoadjuvant therapy versus standard therapy in locally advanced rectal cancer: a systematic review and meta-analysis of 15 trials
X Zhang, S Ma, Y Guo, Y Luo, L Li - PLoS One, 2022 - journals.plos.org
Background Neoadjuvant chemoradiotherapy (nCRT) before total mesorectal excision
(TME) and followed systemic chemotherapy is widely accepted as the standard therapy for …
(TME) and followed systemic chemotherapy is widely accepted as the standard therapy for …
Tyrosine kinase inhibitors and their unique therapeutic potentialities to combat cancer
Cancer is one of the leading causes of death with a mortality rate of 12%. Although
significant progress has been achieved in cancer research, the effective treatment of cancer …
significant progress has been achieved in cancer research, the effective treatment of cancer …
An experimental strategy unveiling exosomal microRNAs 486-5p, 181a-5p and 30d-5p from hypoxic tumour cells as circulating indicators of high-risk rectal cancer
Tumour hypoxia contributes to poor treatment outcome in locally advanced rectal cancer
(LARC) and circulating extracellular vesicles (EVs) as potential biomarkers of tumour …
(LARC) and circulating extracellular vesicles (EVs) as potential biomarkers of tumour …
LncRNA PART1 regulates colorectal cancer via targeting miR-150-5p/miR-520h/CTNNB1 and activating Wnt/β-catenin pathway
T Zhou, L Wu, N Ma, F Tang, Z Zong, S Chen - The International Journal of …, 2020 - Elsevier
Numerous studies have reported that lncRNAs could play a significant role in
carcinogenesis. PART1, as an identified lncRNA, was an oncogene in several cancers …
carcinogenesis. PART1, as an identified lncRNA, was an oncogene in several cancers …
Alliance A022104/NRG-GI010: The Janus Rectal Cancer Trial: a randomized phase II/III trial testing the efficacy of triplet versus doublet chemotherapy regarding …
Background Recent data have demonstrated that in locally advanced rectal cancer (LARC),
a total neoadjuvant therapy (TNT) approach improves compliance with chemotherapy and …
a total neoadjuvant therapy (TNT) approach improves compliance with chemotherapy and …
Molecular and kinetic analyses of circulating tumor cells as predictive markers of treatment response in locally advanced rectal cancer patients
Neoadjuvant chemoradiation (NCRT) followed by total mesorectal excision is the standard
treatment for locally advanced rectal cancer (LARC). To justify a non-surgical approach …
treatment for locally advanced rectal cancer (LARC). To justify a non-surgical approach …
Outcomes of Locally Advanced Rectal Cancer Patients Treated with Total Neoadjuvant Treatment: A Meta-Anaysis of Randomized Controlled Trials
M Gabbani, C Giorgi, G Napoli, U Tebano… - Clinical Colorectal …, 2022 - Elsevier
Abstract Background & Aims Determining outcomes using the total neoadjuvant therapy
(TNT) in patients with local advanced rectal cancer is important for stratifying patients …
(TNT) in patients with local advanced rectal cancer is important for stratifying patients …
Predicting prognosis according to preoperative chemotherapy response in patients with locally advanced lower rectal cancer
T Shiraishi, T Sasaki, K Ikeda, Y Tsukada, Y Nishizawa… - BMC cancer, 2019 - Springer
Background Neoadjuvant chemoradiotherapy is regarded as the standard of treatment for
locally advanced lower rectal cancer, although some of these cases are systemic, and …
locally advanced lower rectal cancer, although some of these cases are systemic, and …
Advances in the treatment of locally advanced rectal cancer
F Ali, A Keshinro, MR Weiser - Annals of gastroenterological …, 2021 - Wiley Online Library
Locally advanced rectal cancer requires multidisciplinary care. In the United States, most
patients are treated with neoadjuvant chemoradiation delivered over 25‐28 days, total …
patients are treated with neoadjuvant chemoradiation delivered over 25‐28 days, total …