Current clinical and preclinical photosensitizers for use in photodynamic therapy

MR Detty, SL Gibson, SJ Wagner - Journal of medicinal chemistry, 2004 - ACS Publications
A little over 100 years ago, Raab reported the killing of the microorganism paramecia with
the combination of acridine and light. The importance of oxygen in the process was …

Metalated heterocycles and their applications in synthetic organic chemistry

R Chinchilla, C Nájera, M Yus - Chemical reviews, 2004 - ACS Publications
The presence of heterocyclic moieties in all kinds of organic compounds of interest in
biology, pharmacology, optics, electronics, material sciences, and so on is sufficiently known …

In vitro demonstration of the heavy-atom effect for photodynamic therapy

A Gorman, J Killoran, C O'Shea, T Kenna… - Journal of the …, 2004 - ACS Publications
Photodynamic therapy (PDT) is an emerging treatment modality for a range of disease
classes, both cancerous and noncancerous. This has brought about an active pursuit of new …

Carbaporphyrinoid systems

TD Lash - Chemical reviews, 2017 - ACS Publications
Following immediately after the serendipitous discovery of N-confused porphyrins,
remarkably diverse carbaporphyrinoid systems have been synthesized and investigated. By …

Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure

J Seenisamy, S Bashyam, V Gokhale… - Journal of the …, 2005 - ACS Publications
Cationic porphyrins are known to bind to and stabilize different types of G-quadruplexes.
Recent studies have shown the biological relevance of the intramolecular parallel G …

Enhanced photodynamic therapy by improved light energy capture efficiency of porphyrin photosensitizers

Z Tian, H Li, Z Liu, L Yang, C Zhang, J He, W Ai… - … Treatment Options in …, 2023 - Springer
Opinion Statement Photodynamic therapy (PDT) has garnered increasing attention in cancer
treatment because of its advantages such as minimal invasiveness and selective …

Drug delivery systems for phthalocyanines for photodynamic therapy

J Rak, P Pouckova, J Benes, D Vetvicka - Anticancer research, 2019 - ar.iiarjournals.org
The focus of this review is to describe the state-of-art in the development of innovative drug
delivery systems for phthalocyanines as photosensitizers for photodynamic therapy (PDT) …

Porphycenes: Facts and prospects in photodynamic therapy of cancer

JC Stockert, M Cañete, A Juarranz… - Current medicinal …, 2007 - ingentaconnect.com
The photodynamic process induces cell damage and death by the combined effect of a
photosensitizer (PS), visible light, and molecular oxygen, which generate singlet oxygen …

Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy

Y Lin, T Zhou, R Bai, Y **e - Journal of enzyme inhibition and …, 2020 - Taylor & Francis
With the development of photodynamic therapy (PDT), remarkable studies have been
conducted to generate photosensitisers (PSs), especially porphyrin PSs. A variety of …

Recent developments in heteroporphyrins and their analogues

I Gupta, M Ravikanth - Coordination Chemistry Reviews, 2006 - Elsevier
Monoheteroatom substituted porphyrins and diheteroatom substituted porhyrins resulting
from the replacement of one and two nitrogen atoms, respectively, are very stable aromatic …