Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes
has grown substantially, particularly with regard to disease prediction and heterogeneity …

Context: Diabetes is associated with a deficit of insulin-producing β-cells. Animal studies
show that β-cells become dedifferentiated in diabetes, reverting to a progenitor-like stage …

Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for
triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states …

Diabetes is associated with β cell failure. But it remains unclear whether the latter results
from reduced β cell number or function. FoxO1 integrates β cell proliferation with adaptive β …

Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …

Diabetes is characterized by" glucotoxic" loss of pancreatic β cell function and insulin
content, but underlying mechanisms remain unclear. A mouse model of insulin-secretory …

Pdx1 is a homeobox-containing transcription factor that plays a key role in pancreatic
development and adult β cell function. In this study, we traced the fate of adult β cells after …

Islets of Langerhans are fundamental in understanding diabetes. A healthy human pancreas
from a donor has been used to asses various islet parameters and their three-dimensional …

OBJECTIVE We sought to establish β-cell mass, β-cell apoptosis, and β-cell replication in
humans in response to obesity and advanced age. RESEARCH DESIGN AND METHODS …