Cardiogenic shock is usually defined as primary cardiac dysfunction with low cardiac output
leading to critical organ hypoperfusion, and tissue hypoxia, resulting in high mortality rate …

Biomedical research requires both in vitro and in vivo studies in order to explore disease
processes or drug interactions. Foundational investigations have been performed at the …

Over the past decade, the development of three-dimensional (3D) models has increased
exponentially, facilitating the unravelling of fundamental and essential cellular mechanisms …

Cell co-culture technology aims to study the communication mechanism between cells and
to better reveal the interactions and regulatory mechanisms involved in processes such as …

Chagas disease (CD) is the most important endemic parasitosis in South America and
represents a great socioeconomic burden for the chronically ill and their families. The only …

Organoids are small, self-organizing three-dimensional cell cultures that are derived from
stem cells or primary organs. These cultures replicate the complexity of an organ, which …

Nephrotoxicity is a significant concern during the development of new drugs or when
assessing the safety of chemicals in consumer products. Traditional methods for testing …

Microchannels based on microelectromechanical systems (MEMS) have received a lot of
interest in the microfluidics and biomedical fields over the past forty years. While their …

In the field of assisted reproductive technologies, oocyte in vitro maturation (IVM) has
emerged as a potential alternative to overcome the limitations associated with standard …

Background The differences between existing preclinical models and the tumor
microenvironment in vivo are one of the significant challenges hindering cancer therapy …