In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

Single‐cell RNA sequencing (scRNA‐seq) technology has become the state‐of‐the‐art
approach for unravelling the heterogeneity and complexity of RNA transcripts within …

In recent years, tumor immunotherapy has made significant progress. However, tumor
immunotherapy, particularly immune checkpoint inhibitors (eg, PD-1/PD-L1 inhibitors) …

Pericytes are known as the mural cells in small-caliber vessels that interact closely with the
endothelium. Pericytes play a key role in vasculature formation and homeostasis, and when …

As angiogenesis was recognized as a core hallmark of cancer growth and survival, several
strategies have been implemented to target the tumour vasculature. Yet to date, attempts …

Research into the mechanisms and manifestations of solid tumor vascularization was
launched more than 50 years ago with the proposition and experimental demonstrations that …

The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a
key player in pathogenic ocular neovascularization almost a decade ago. Since then, an …

Tumours can obtain nutrients and oxygen required to progress and metastasize through the
blood supply. Inducing angiogenesis involves the sprouting of established vessel beds and …

Pigs are valuable large animal models for biomedical and genetic research, but insights into
the tissue-and cell-type-specific transcriptome and heterogeneity remain limited. By …