By targeting invasive organisms, antibiotics insert themselves into the ancient struggle of the
host-pathogen evolutionary arms race. As pathogens evolve tactics for evading antibiotics …

In general perturbation methods starts with a known exact solution of a problem and add
“small” variation terms in order to approach to a solution for a related problem without known …

Drug-target interaction (DTI) is a key aspect in pharmaceutical research. With the ever-
increasing new drug data resources, computational approaches have emerged as powerful …

Predicting drug-target interactions is important for the development of novel drugs and the
repositioning of drugs. To predict such interactions, there are a number of methods based on …

HIGHLIGHTS Many CNS targets are being explored for multi-target drug design New
databases and cheminformatic methods enable prediction of primary pharmaceutical target …

Alzheimer's disease (AD) is a chronic neurodegenerative disease which leads to the
gradual loss of neuronal cells. Several hypotheses for AD exists (eg, cholinergic, amyloid …

Background: Neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic
lateral sclerosis, Parkinson's disease (PD), spinal cerebellar ataxias, and spinal and bulbar …

This work is aimed at describing the workflow for a methodology that combines
chemoinformatics and pharmacoepidemiology methods and at reporting the first predictive …

Pancreatic cancers are widely recognized as a group of neoplasms with one of the poorest
prognoses in oncology research. Despite the advances achieved in drug design and …

Inflammation involves a complex biological response of the body tissues to damaging
stimuli. When dysregulated, inflammation led by biomolecular mediators such as caspase-1 …