Delirium

JE Wilson, MF Mart, C Cunningham… - Nature Reviews …, 2020 - nature.com
Delirium, a syndrome characterized by an acute change in attention, awareness and
cognition, is caused by a medical condition that cannot be better explained by a pre-existing …

The inter-relationship between delirium and dementia: the importance of delirium prevention

TG Fong, SK Inouye - Nature Reviews Neurology, 2022 - nature.com
Delirium and dementia are two frequent causes of cognitive impairment among older adults
and have a distinct, complex and interconnected relationship. Delirium is an acute …

Long-term cognitive impairment after acute respiratory distress syndrome: a review of clinical impact and pathophysiological mechanisms

C Sasannejad, EW Ely, S Lahiri - Critical care, 2019 - Springer
Acute respiratory distress syndrome (ARDS) survivors experience a high prevalence of
cognitive impairment with concomitantly impaired functional status and quality of life, often …

Cerebral dysfunctions caused by sepsis during ageing

T Manabe, MT Heneka - Nature Reviews Immunology, 2022 - nature.com
Systemic inflammation elicited by sepsis can induce an acute cerebral dysfunction known as
sepsis-associated encephalopathy (SAE). Recent evidence suggests that SAE is common …

The interface between delirium and dementia in elderly adults

TG Fong, D Davis, ME Growdon… - The Lancet …, 2015 - thelancet.com
Delirium and dementia are two of the most common causes of cognitive impairment in older
populations, yet their interrelation remains poorly understood. Previous studies have shown …

Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL‐1β drives amplified responses in primed astrocytes and neuronal network …

AB Lopez‐Rodriguez, E Hennessy… - Alzheimer's & …, 2021 - Wiley Online Library
Neuroinflammation contributes to Alzheimer's disease (AD) progression. Secondary
inflammatory insults trigger delirium and can accelerate cognitive decline. Individual cellular …

The consistent burden in published estimates of delirium occurrence in medical inpatients over four decades: a systematic review and meta-analysis study

K Gibb, A Seeley, T Quinn, N Siddiqi, S Shenkin… - Age and …, 2020 - academic.oup.com
Introduction Delirium is associated with a wide range of adverse patient safety outcomes, yet
it remains consistently under-diagnosed. We undertook a systematic review of studies …

Update of the European Society of Anaesthesiology and Intensive Care Medicine evidence-based and consensus-based guideline on postoperative delirium in adult …

C Aldecoa, G Bettelli, F Bilotta… - European Journal of …, 2024 - journals.lww.com
Update of the European Society of Anaesthesiology and Intens... : European Journal of
Anaesthesiology | EJA Update of the European Society of Anaesthesiology and Intensive Care …

Postoperative delirium is associated with increased plasma neurofilament light

CP Casey, H Lindroth, R Mohanty, Z Farahbakhsh… - Brain, 2020 - academic.oup.com
While delirium is associated with cognitive decline and dementia, there is limited evidence
to support causality for this relationship. Clarification of how delirium may cause cognitive …

Priming microglia for innate immune memory in the brain

JJ Neher, C Cunningham - Trends in immunology, 2019 - cell.com
Microglia, the resident macrophages of the brain, are highly plastic and well known to be pre-
activated or 'primed'by active inflammatory processes, resulting in amplified responses to a …