Acute graft-versus-host disease

F Malard, E Holler, BM Sandmaier, H Huang… - Nature Reviews …, 2023 - nature.com
Acute graft-versus-host disease (GVHD) is a common immune complication that can occur
after allogeneic haematopoietic cell transplantation (alloHCT). Acute GVHD is a major …

EBMT/ESID inborn errors working party guidelines for hematopoietic stem cell transplantation for inborn errors of immunity

AC Lankester, MH Albert, C Booth… - Bone Marrow …, 2021 - nature.com
Inborn errors of immunity (IEI) are a group of rare heterogeneous diseases. Currently, more
than 400 monogenetic IEI have been identified and increasingly a genetic diagnosis can be …

[HTML][HTML] National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: IIa. The 2020 clinical …

CL Kitko, J Pidala, HM Schoemans… - … and cellular therapy, 2021 - Elsevier
Recognition of the earliest signs and symptoms of chronic graft-versus-host disease (GVHD)
that lead to severe manifestations remains a challenge. The standardization provided by the …

Reduced post-transplant cyclophosphamide dose with antithymocyte globulin in peripheral blood stem cell haploidentical transplantation

R Duléry, F Malard, E Brissot, A Banet… - Bone Marrow …, 2023 - nature.com
Post-transplant cyclophosphamide (PT-Cy) is effective for graft-versus-host disease (GVHD)
prophylaxis, but it may cause dose-dependent toxicities, particularly in frail patients …

Relationship of donor age and relationship to outcomes of haploidentical transplantation with posttransplant cyclophosphamide

AE DeZern, C Franklin, HL Tsai, PH Imus… - Blood …, 2021 - ashpublications.org
Allogeneic blood or marrow transplantation (BMT) physicians seek to optimize all possible
variables to improve outcomes. Selectable factors include conditioning, graft-versus-host …

How I prevent GVHD in high-risk patients: posttransplant cyclophosphamide and beyond

J Rimando, SR McCurdy, L Luznik - Blood, 2023 - ashpublications.org
Advances in conditioning, graft-versus-host disease (GVHD) prophylaxis and antimicrobial
prophylaxis have improved the safety of allogeneic hematopoietic cell transplantation (HCT) …

Combining post-transplant cyclophosphamide with antithymocyte globulin for graft-versus-host disease prophylaxis in hematological malignancies

R Duléry, E Brissot, M Mohty - Blood Reviews, 2023 - Elsevier
In search of an ideal partner or alternative to conventional immunosuppressive agents,
rabbit anti-thymocyte globulin (ATG) and, more recently, post-transplant cyclophosphamide …

Reduced dose of posttransplant cyclophosphamide in HLA-haploidentical peripheral blood stem cell transplantation

J Sugita, T Kamimura, T Ishikawa, S Ota, T Eto… - Bone marrow …, 2021 - nature.com
Abstract Posttransplant cyclophosphamide (PTCy: 100 mg/kg) has been increasingly used
in allogeneic hematopoietic stem cell transplantation, however, few studies compared …

Post-transplant cyclophosphamide containing regimens after matched sibling, matched unrelated and haploidentical donor transplants in patients with acute …

J Sanz, JE Galimard, M Labopin, B Afanasyev… - Journal of Hematology & …, 2021 - Springer
Background There is no information on the impact of donor type in allogeneic hematopoietic
stem cell transplantation (HCT) using homogeneous graft-versus-host (GVHD) prophylaxis …

Antibody-drug conjugates plus Janus kinase inhibitors enable MHC-mismatched allogeneic hematopoietic stem cell transplantation

SP Persaud, JK Ritchey, S Kim, S Lim… - The Journal of …, 2021 - Am Soc Clin Investig
Despite the curative potential of hematopoietic stem cell transplantation (HSCT),
conditioning-associated toxicities preclude broader clinical application. Antibody-drug …