The purpose of this review is to assess the state-of-the-art fabrication methods, advances in
genome editing, and the use of machine learning to shape the prospective growth in cardiac …

Cardiac regeneration, that is, restoration of the original structure and function in a damaged
heart, differs from tissue repair, in which collagen deposition and scar formation often lead to …

Mammalian neocortical neurons span one of the most diverse cell type spectra of any tissue.
Cortical neurons are born during embryonic development, and their maturation extends into …

Rationale: We hypothesized that the differentiation processes of cardiac progenitor cell (CP)
from first and second heart fields (FHF and SHF) may undergo the unique instructive gene …

During development, mesodermal progenitors from the first heart field (FHF) form a primitive
cardiac tube, to which progenitors from the second heart field (SHF) are added. The …

Mammalian heart development relies on cardiomyocyte mitochondrial maturation and
metabolism. Embryonic cardiomyocytes make a metabolic shift from anaerobic glycolysis to …

Determining genes that orchestrate cell differentiation in development and disease remains
a fundamental goal of cell biology. This study establishes a genome-wide metric based on …

Background Cardiac differentiation from human pluripotent stem cells provides a unique
opportunity to study human heart development in vitro and offers a potential cell source for …

Abstract miRNAs modulate cardiomyocyte specification by targeting mRNAs of cell cycle
regulators and acting in cardiac muscle lineage gene regulatory loops. It is unknown if or to …

Genome-wide association studies have identified over 200 genetic loci associated with
inflammatory bowel disease; however, the mechanism of such a large amount of …