Mechanisms of action of fluvoxamine for COVID-19: a historical review
Y Hashimoto, T Suzuki, K Hashimoto - Molecular psychiatry, 2022 - nature.com
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) accelerates the discovery of …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) accelerates the discovery of …
[HTML][HTML] Fluvoxamine: a review of its mechanism of action and its role in COVID-19
Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake
inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized …
inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized …
Structures of the σ2 receptor enable docking for bioactive ligand discovery
The σ2 receptor has attracted intense interest in cancer imaging, psychiatric disease,
neuropathic pain,–and other areas of biology,. Here we determined the crystal structure of …
neuropathic pain,–and other areas of biology,. Here we determined the crystal structure of …
Crystal structure of the human σ1 receptor
The human σ1 receptor is an enigmatic endoplasmic-reticulum-resident transmembrane
protein implicated in a variety of disorders including depression, drug addiction, and …
protein implicated in a variety of disorders including depression, drug addiction, and …
Indole in the target-based design of anticancer agents: A versatile scaffold with diverse mechanisms
S Dadashpour, S Emami - European journal of medicinal chemistry, 2018 - Elsevier
The indole scaffold is one of the most widespread heterocycles in the naturally occurring
and synthetic bioactive compounds including anticancer agents. Due to its biodiversity and …
and synthetic bioactive compounds including anticancer agents. Due to its biodiversity and …
Repurposing of CNS drugs to treat COVID-19 infection: targeting the sigma-1 receptor
K Hashimoto - European archives of psychiatry and clinical …, 2021 - Springer
The novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). The escalating number of SARS-CoV-2-infected …
syndrome coronavirus 2 (SARS-CoV-2). The escalating number of SARS-CoV-2-infected …
Identification of the gene that codes for the σ2 receptor
The σ2 receptor is an enigmatic protein that has attracted significant attention because of its
involvement in diseases as diverse as cancer and neurological disorders. Unlike virtually all …
involvement in diseases as diverse as cancer and neurological disorders. Unlike virtually all …
The sigma-1 receptor as a pluripotent modulator in living systems
The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum (ER) protein that resides
specifically in the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) …
specifically in the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) …
[HTML][HTML] Neuronal sigma-1 receptors: signaling functions and protective roles in neurodegenerative diseases
Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca2+ signaling and cell survival
T Hayashi, TP Su - Cell, 2007 - cell.com
Communication between the endoplasmic reticulum (ER) and mitochondrion is important for
bioenergetics and cellular survival. The ER supplies Ca 2+ directly to mitochondria via …
bioenergetics and cellular survival. The ER supplies Ca 2+ directly to mitochondria via …