Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in
regulating multiple signal transduction pathways that influence a diverse range of cellular …

Growth factor signaling plays a pivotal role in diverse biological functions, such as cell
growth, apoptosis, senescence, and migration and its deregulation has been linked to …

Background Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with
an overall 5-year survival rate of less than 8%. New evidence indicates that PDAC cells …

CBP/p300, functioning as histone acetyltransferases and transcriptional co-factors,
represents an attractive target for various diseases, including malignant tumor. The …

Skp2 E3 ligase is overexpressed in numerous human cancers and plays a critical role in cell-
cycle progression, senescence, metabolism, cancer progression, and metastasis. In the …

Akt kinase plays a central role in cell growth, metabolism, and tumorigenesis. The TRAF6 E3
ligase orchestrates IGF-1-mediated Akt ubiquitination and activation. Here, we show that Akt …

Breast cancer is the second leading cancer among all types of cancers. It accounts for 12%
of the total cases of cancers. The complex and heterogeneous nature of breast cancer …

Strictly regulated protein degradation by ubiquitin-proteasome system (UPS) is essential for
various cellular processes whose dysregulation is linked to serious diseases including …

Diffuse brain infiltration by glioma cells causes detrimental disease progression, but its
multicellular coordination is poorly understood. We show here that glioma cells infiltrate the …

The ubiquitin‐proteasome system (UPS) is a complex process that regulates protein stability
and activity by the sequential actions of E1, E2 and E3 enzymes to influence diverse aspects …