Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …

Abstract Alzheimer's disease (AD), the most common cause of dementia, results in a
sustained decline in cognition. There are currently few effective disease modifying therapies …

Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional
remodeling in response to injury, disease, or infection of the CNS. Although this remodeling …

Astrocytes are neural parenchymal cells that ubiquitously tile the central nervous system
(CNS). In addition to playing essential roles in healthy tissue, astrocytes exhibit an …

There is increasing appreciation that non-neuronal cells contribute to the initiation,
progression and pathology of diverse neurodegenerative disorders. This Review focuses on …

Astrocytes are critical components of the neurovascular unit that support blood-brain barrier
(BBB) function. Pathological transformation of astrocytes to reactive states can be protective …

Astrocytes, one of the largest glial cell population in the central nervous system (CNS), play
a key function in several events of brain development and function, such as synapse …

Astrocytes are the most abundant glial cells in the central nervous system (CNS) and
participate in synaptic, circuit, and behavioral functions. The well‐developed protoplasmic …

Astrocytes are key cellular partners for neurons in the central nervous system. Astrocytes
react to virtually all types of pathological alterations in brain homeostasis by significant …

Neuroinflammation contributes to Alzheimer's disease (AD) progression. Secondary
inflammatory insults trigger delirium and can accelerate cognitive decline. Individual cellular …