Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets.
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …

Arginine methylation is a common post-translational modification functioning as an
epigenetic regulator of transcription and playing key roles in pre-mRNA splicing, DNA …

Cytoplasmic FUS aggregates are a pathological hallmark in a subset of patients with
frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). A key step that is …

Neutrophils release neutrophil extracellular traps (NETs) which ensnare pathogens and
have pathogenic functions in diverse diseases. We examined the NETosis pathways …

Over 500 natural and synthetic amino acids have been genetically encoded in the last two
decades. Incorporating these noncanonical amino acids into proteins enables many …

Advances in genomics and proteomics have revealed eukaryotic proteomes to be highly
abundant in intrinsically disordered proteins that are susceptible to diverse post-translational …

Following its predecessor, the second edition of Amino Acids: Biochemistry and Nutrition
presents exhaustive coverage of amino acids in the nutrition, metabolism and health of …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Immunology, already a discipline in its own right, has become a major part of many different
medical fields. However, its relationship to orthopedics and trauma surgery has …

As a predominant type II protein arginine methyltransferase, PRMT5 plays critical roles in
various normal cellular processes by catalyzing the mono-and symmetrical dimethylation of …