Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability

H Wang, T Oo Khor, L Shu, ZY Su… - Anti-Cancer Agents …, 2012‏ - ingentaconnect.com
Cancer remains to be one of the leading causes of death in the United States and around
the world. The advent of modern drug-targeted therapies has undeniably improved cancer …

[HTML][HTML] Modulation of Nrf2 and NF-κB signaling pathways by naturally occurring compounds in relation to cancer prevention and therapy. Are combinations better …

V Krajka-Kuźniak, W Baer-Dubowska - International Journal of Molecular …, 2021‏ - mdpi.com
Nrf2 (nuclear factor erythroid 2-related factor 2) and NF-κB (nuclear factor–kappa B)
signaling pathways play a central role in suppressing or inducing inflammation and …

The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: involvement of the Nrf2-ARE signaling pathway

CLL Saw, Y Guo, AY Yang, X Paredes-Gonzalez… - Food and Chemical …, 2014‏ - Elsevier
Quercetin, kaempferol, and pterostilbene are abundant in berries. The anti-oxidative
properties of these constituents may contribute to cancer chemoprevention. However, their …

Indoles derived from glucobrassicin: cancer chemoprevention by indole-3-carbinol and 3, 3'-diindolylmethane

DE Williams - Frontiers in Nutrition, 2021‏ - frontiersin.org
Hydrolysis of glucobrassicin by plant or bacterial myrosinase produces multiple indoles
predominantly indole-3-carbinol (I3C). I3C and its major in vivo product, 3, 3' …

Phenethyl isothiocyanate: A comprehensive review of anti-cancer mechanisms

P Gupta, SE Wright, SH Kim, SK Srivastava - Biochimica et Biophysica Acta …, 2014‏ - Elsevier
The epidemiological evidence suggests a strong inverse relationship between dietary intake
of cruciferous vegetables and the incidence of cancer. Among other constituents of …

Multiple regulations of Keap1/Nrf2 system by dietary phytochemicals

S Qin, DX Hou - Molecular nutrition & food research, 2016‏ - Wiley Online Library
Keap1/Nrf2 system plays a critical role on cellular protection by regulating many antioxidant
and detoxification enzyme genes through the antioxidant response element (ARE). Thus, it …

Mechanisms underlying biological effects of cruciferous glucosinolate-derived isothiocyanates/indoles: a focus on metabolic syndrome

M Esteve - Frontiers in Nutrition, 2020‏ - frontiersin.org
An inverse correlation between vegetable consumption and the incidence of cancer has
long been described. This protective effect is stronger when cruciferous vegetables are …

Dietary glucosinolates sulforaphane, phenethyl isothiocyanate, indole-3-carbinol/3, 3′-diindolylmethane: Antioxidative stress/inflammation, Nrf2, epigenetics …

F Fuentes, X Paredes-Gonzalez, ANT Kong - Current pharmacology …, 2015‏ - Springer
Glucosinolates are a group of sulfur-containing glycosides found in many plant species,
including cruciferous vegetables such as broccoli, cabbage, Brussels sprouts, and …

Molecular targets of isothiocyanates in cancer: recent advances

P Gupta, B Kim, SH Kim… - Molecular nutrition & food …, 2014‏ - Wiley Online Library
Cancer is a multistep process resulting in uncontrolled cell division. It results from aberrant
signaling pathways that lead to uninhibited cell division and growth. Various recent …

Modulation of CYP1A1 metabolism: From adverse health effects to chemoprevention and therapeutic options

M Mescher, T Haarmann-Stemmann - Pharmacology & therapeutics, 2018‏ - Elsevier
The human cytochrome P450 (CYP) 1A1 gene encodes a monooxygenase that metabolizes
multiple exogenous and endogenous substrates. CYP1A1 has become infamous for its …