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Physiological and pathological roles of lipogenesis
Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …
Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators
Countless times each day, the acute inflammatory response protects us from invading
microbes, injuries, and insults from within, as in surgery-induced tissue injury. These …
microbes, injuries, and insults from within, as in surgery-induced tissue injury. These …
Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain
The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …
Specialized pro-resolving mediators in vascular inflammation and atherosclerotic cardiovascular disease
Timely resolution of the acute inflammatory response (or inflammation resolution) is an
active, highly coordinated process that is essential to optimal health. Inflammation resolution …
active, highly coordinated process that is essential to optimal health. Inflammation resolution …
Epigenetic clock analysis of diet, exercise, education, and lifestyle factors
Behavioral and lifestyle factors have been shown to relate to a number of health-related
outcomes, yet there is a need for studies that examine their relationship to molecular aging …
outcomes, yet there is a need for studies that examine their relationship to molecular aging …
Resolution of inflammation: a new therapeutic frontier
Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …
[HTML][HTML] Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms
Practitioners of ancient societies from the time of Hippocrates and earlier recognized and
treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or …
treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or …
Pro-resolving lipid mediators are leads for resolution physiology
Advances in our understanding of the mechanisms that bring about the resolution of acute
inflammation have uncovered a new genus of pro-resolving lipid mediators that include the …
inflammation have uncovered a new genus of pro-resolving lipid mediators that include the …
[PDF][PDF] Specialized pro-resolving mediators: endogenous regulators of infection and inflammation
Specialized pro-resolving mediators (SPMs) are enzymatically derived from essential fatty
acids and have important roles in orchestrating the resolution of tissue inflammation—that is …
acids and have important roles in orchestrating the resolution of tissue inflammation—that is …
Inflammatory and immune pathways in the pathogenesis of periodontal disease
The pathogenesis of periodontitis involves a complex immune/inflammatory cascade that is
initiated by the bacteria of the oral biofilm that forms naturally on the teeth. The susceptibility …
initiated by the bacteria of the oral biofilm that forms naturally on the teeth. The susceptibility …