Neprilysin and Aβ clearance: impact of the APP intracellular domain in NEP regulation and implications in Alzheimer's disease
MOW Grimm, J Mett, CP Stahlmann… - Frontiers in aging …, 2013 - frontiersin.org
One of the characteristic hallmarks of Alzheimer's disease (AD) is an accumulation of
amyloid β (Aβ) leading to plaque formation and toxic oligomeric Aβ complexes. Besides the …
amyloid β (Aβ) leading to plaque formation and toxic oligomeric Aβ complexes. Besides the …
Molecular basis of selective amyloid‐β degrading enzymes in Alzheimer's disease
The accumulation of the small 42‐residue long peptide amyloid‐β (Aβ) has been proposed
as a major trigger for the development of Alzheimer's disease (AD). Within the brain, the …
as a major trigger for the development of Alzheimer's disease (AD). Within the brain, the …
Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer's disease
In addition to the devastating symptoms of dementia, Alzheimer's disease (AD) is
characterized by accumulation of the processing products of the amyloid-β (Aβ) peptide …
characterized by accumulation of the processing products of the amyloid-β (Aβ) peptide …
[HTML][HTML] Phosphorylation of amyloid beta (Aβ) peptides–A trigger for formation of toxic aggregates in Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia and associated with the
progressive accumulation of amyloid β-peptides (Aβ) in form of extracellular amyloid …
progressive accumulation of amyloid β-peptides (Aβ) in form of extracellular amyloid …
MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced …
Alzheimer disease (AD) results, in part, from the excess accumulation of the amyloid-β (Aβ)
peptide as neuritic plaques in the brain. The short Aβ peptide is derived from the large …
peptide as neuritic plaques in the brain. The short Aβ peptide is derived from the large …
An integrative toxicogenomic analysis of plastic additives
In developed countries, contact with plastics is constant. Plastics contain a vast number of
additives such as plasticisers, stabilisers, antioxidants, flame retardants, etc., that can impact …
additives such as plasticisers, stabilisers, antioxidants, flame retardants, etc., that can impact …
Are amyloid‐degrading enzymes viable therapeutic targets in Alzheimer's disease?
NN Nalivaeva, C Beckett, ND Belyaev… - Journal of …, 2012 - Wiley Online Library
J. Neurochem.(2012) 120 (Suppl. 1), 167–185. Abstract The amyloid cascade hypothesis of
Alzheimer's disease envisages that the initial elevation of amyloid β‐peptide (Aβ) levels …
Alzheimer's disease envisages that the initial elevation of amyloid β‐peptide (Aβ) levels …
Gene biomarker discovery at different stages of Alzheimer using gene co-expression network approach
Alzheimer's disease (AD) is a chronic neurodegenerative disorder. It is the most common
type of dementia that has remained as an incurable disease in the world, which destroys the …
type of dementia that has remained as an incurable disease in the world, which destroys the …
[HTML][HTML] Ashwagandha (Withania somnifera) reverses β-amyloid1-42 induced toxicity in human neuronal cells: implications in HIV-associated neurocognitive …
Alzheimer's disease (AD) is characterized by progressive dysfunction of memory and higher
cognitive functions with abnormal accumulation of extracellular amyloid plaques and …
cognitive functions with abnormal accumulation of extracellular amyloid plaques and …
BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's disease
L Chami, F Checler - Molecular neurodegeneration, 2012 - Springer
Alzheimer's disease (AD) is a complex age-related pathology, the etiology of which has not
been firmly delineated. Among various histological stigmata, AD-affected brains display …
been firmly delineated. Among various histological stigmata, AD-affected brains display …