Nanozymes for nanohealthcare

Y Zhang, G Wei, W Liu, T Li, Y Wang, M Zhou… - Nature Reviews …, 2024‏ - nature.com
Nanozymes, nanomaterial-based artificial enzymes, exhibit potential for emulating the
catalytic functions inherent in enzymes. Nanozymes have advantages such as low cost …

The physical frailty syndrome as a transition from homeostatic symphony to cacophony

LP Fried, AA Cohen, QL Xue, J Walston… - Nature aging, 2021‏ - nature.com
Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to
adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence …

Predicting transcriptional outcomes of novel multigene perturbations with GEARS

Y Roohani, K Huang, J Leskovec - Nature Biotechnology, 2024‏ - nature.com
Understanding cellular responses to genetic perturbation is central to numerous biomedical
applications, from identifying genetic interactions involved in cancer to develo** methods …

Frailty: implications for clinical practice and public health

EO Hoogendijk, J Afilalo, KE Ensrud, P Kowal, G Onder… - The Lancet, 2019‏ - thelancet.com
Frailty is an emerging global health burden, with major implications for clinical practice and
public health. The prevalence of frailty is expected to rise alongside rapid growth in the …

A complex systems approach to aging biology

AA Cohen, L Ferrucci, T Fülöp, D Gravel, N Hao… - Nature aging, 2022‏ - nature.com
Having made substantial progress understanding molecules, cells, genes and pathways,
aging biology research is now moving toward integration of these parts, attempting to …

General design strategy to precisely control the emission of fluorophores via a twisted intramolecular charge transfer (TICT) process

K Hanaoka, S Iwaki, K Yagi, T Myochin… - Journal of the …, 2022‏ - ACS Publications
Fluorogenic probes for bioimaging have become essential tools for life science and
medicine, and the key to their development is a precise understanding of the mechanisms …

[HTML][HTML] Impact of climate change on crops adaptation and strategies to tackle its outcome: A review

A Raza, A Razzaq, SS Mehmood, X Zou, X Zhang, Y Lv… - Plants, 2019‏ - mdpi.com
Agriculture and climate change are internally correlated with each other in various aspects,
as climate change is the main cause of biotic and abiotic stresses, which have adverse …

Use of zebrafish in drug discovery toxicology

S Cassar, I Adatto, JL Freeman, JT Gamse… - Chemical research in …, 2019‏ - ACS Publications
Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

[HTML][HTML] Chlorogenic acid (CGA): A pharmacological review and call for further research

M Naveed, V Hejazi, M Abbas, AA Kamboh… - Biomedicine & …, 2018‏ - Elsevier
Phenolic acids have recently gained substantial attention due to their various practical,
biological and pharmacological effects. Chlorogenic Acid (CGA, 3-CQA) is a most abundant …

Integration of GC–MS and LC–MS for untargeted metabolomics profiling

ÖC Zeki, CC Eylem, T Reçber, S Kır… - Journal of Pharmaceutical …, 2020‏ - Elsevier
Recently, metabolomics analyses have become increasingly common in the general
scientific community as it is applied in several researches relating to diseases diagnosis …