Simple Summary Estrogens, belonging to a group of steroid compounds, play an important
role in both physiological and disease processes, mainly by interacting with estrogen …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a
key role in reproduction and exerting functions in numerous nonreproductive tissues. In this …

Nineteen years have passed since our previous review in this journal in 1999 regarding
estrogen receptors. At that time, we described the current assessments of the physiological …

Histone deacetylase (HDAC) inhibitors are powerful epigenetic regulators that have
enormous therapeutic potential and have pleiotropic effects at the cellular and systemic …

Histone deacetylase (HDAC) inhibitors are a relatively new class of anti-cancer agents that
play important roles in epigenetic or non-epigenetic regulation, inducing death, apoptosis …

Since the first report of p53 as a non-histone target of a histone acetyltransferase (HAT),
there has been a rapid proliferation in the description of new non-histone targets of HATs. Of …

Histone deacetylase inhibitors (HDACi) comprise structurally diverse compounds that are a
group of targeted anticancer agents. The first of these new HDACi, vorinostat …

Nuclear receptors are major targets for drug discovery and have key roles in development
and homeostasis, as well as in many diseases such as obesity, diabetes and cancer. This …

There is now a large body of evidence suggesting that the decline in ovarian function with
menopause is associated with spontaneous increases in proinflammatory cytokines. The …