European guideline and expert statements on the management of narcolepsy in adults and children
Background and aim Narcolepsy is an uncommon hypothalamic disorder of presumed
autoimmune origin that usually requires lifelong treatment. This paper aims to provide …
autoimmune origin that usually requires lifelong treatment. This paper aims to provide …
The integrated brain network that controls respiration
Respiration is a brain function on which our lives essentially depend. Control of respiration
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …
[HTML][HTML] Oral orexin receptor 2 agonist in narcolepsy type 1
Background Narcolepsy type 1 is caused by severe loss or lack of brain orexin
neuropeptides. Methods We conducted a phase 2, randomized, placebo-controlled trial of …
neuropeptides. Methods We conducted a phase 2, randomized, placebo-controlled trial of …
Understanding and approaching excessive daytime sleepiness
Excessive daytime sleepiness (EDS) is a public health issue. However, it remains largely
undervalued, scarcely diagnosed, and poorly supported. Variations in the definition of EDS …
undervalued, scarcely diagnosed, and poorly supported. Variations in the definition of EDS …
Sleep disorders and cancer: State of the art and future perspectives
A bidirectional connection between sleep and cancer exists; however, the specific
associations between individual sleep disorders and particular tumors are not very clear. An …
associations between individual sleep disorders and particular tumors are not very clear. An …
Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy
Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic
neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune …
neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune …
Orexin 2 receptor–selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients
R Evans, H Kimura, R Alexander… - Proceedings of the …, 2022 - National Acad Sciences
Narcolepsy type 1 (NT1) is a sleep disorder caused by a loss of orexinergic neurons.
Narcolepsy type 2 (NT2) is heterogeneous; affected individuals typically have normal orexin …
Narcolepsy type 2 (NT2) is heterogeneous; affected individuals typically have normal orexin …
[HTML][HTML] Diagnosis of central disorders of hypersomnolence: a reappraisal by European experts
GJ Lammers, CLA Bassetti, L Dolenc-Groselj… - Sleep medicine …, 2020 - Elsevier
The aim of this European initiative is to facilitate a structured discussion to improve the next
edition of the International Classification of Sleep Disorders (ICSD), particularly the chapter …
edition of the International Classification of Sleep Disorders (ICSD), particularly the chapter …
Excessive daytime sleepiness: a clinical review
KD Gandhi, MP Mansukhani, MH Silber… - Mayo Clinic …, 2021 - Elsevier
Excessive daytime sleepiness (EDS) is a highly prevalent condition that is associated with
significant morbidity. The causes of EDS are varied, and include inadequate sleep, sleep …
significant morbidity. The causes of EDS are varied, and include inadequate sleep, sleep …
Deficiency of orexin signaling during sleep is involved in abnormal REM sleep architecture in narcolepsy
Narcolepsy is a sleep disorder caused by deficiency of orexin signaling. However, the
neural mechanisms by which deficient orexin signaling causes the abnormal rapid eye …
neural mechanisms by which deficient orexin signaling causes the abnormal rapid eye …